Publications by Marco Capogrosso

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Tomislav Milekovic, Léonie Asboth, Camille Georgette Marie Le Goff-Mignardot, Giuseppe Schiavone, Elvira Pirondini, Stéphanie Lacour, Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, David Allenson Borton, Jean François Pierre Laurens, Jean-Baptiste Mignardot, Flavio Raschella, Robin Jonathan Demesmaeker, Simon Borgognon, Jocelyne Bloch, Shiqi Sun, Sergio Daniel Hernandez, Jordan Squair, Nicolò Macellari, Jimmy James Ravier, Carmina Andrea Galvez Solano, Grégory Didier Dumont

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Dimitri Nestor Alice Van De Ville, Léonie Asboth, Nawal Noëlle Kinany, Salif Axel Komi, Silvestro Micera, Grégoire Courtine, Miroslav Caban, Quentin Barraud, Marco Capogrosso, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Nathan Antoine Greiner, Jocelyne Bloch, Sergio Daniel Hernandez, Laura Ann McCracken, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Carmina Andrea Galvez Solano

Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal ...

NATURE PORTFOLIO2022

System for planning and/or providing neuromodulation

Vincent Delattre, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian

The present invention relates to systems and methods for planning and/or providing neuromodulation One example system includesa stimulation related basic data storage module for storing stimulation related basic data,a stimulation related response data sto ...

2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Jérôme Gandar, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Salif Axel Komi, Stéphanie Lacour, Arnaud Bichat, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Eduardo Martin Moraud, Marco Capogrosso, Mark Andrew Anderson, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Ileana Ozana Jelescu, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Laura Ann McCracken, Matthieu Pierre Gautier, Loïs Thomas Romain Mahe, Jimmy James Ravier

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Spatiotemporal Maps of Proprioceptive Inputs to the Cervical Spinal Cord During Three-Dimensional Reaching and Grasping

Auke Ijspeert, Pierre Charles Marie Kibleur, Marco Capogrosso, Sara Conti, Nathan Antoine Greiner, Beatrice Barra, Shravan Tata Ramalingasetty

Proprioceptive feedback is a critical component of voluntary movement planning and execution. Neuroprosthetic technologies aiming at restoring movement must interact with it to restore accurate motor control. Optimization and design of such technologies de ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2020

Soft, Implantable Bioelectronic Interfaces for Translational Research

Sébastien Jiguet, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Evgenia Vladimirova Roussinova, Ivan Furfaro, Andreas Rowald, Beatrice Barra, Simon Borgognon, Jocelyne Bloch, Xiaoyang Kang, Ismael Seanez Gonzalez

The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐based innovation toward cli ...

Wiley2020

A system for providing neuromodulation, especially neurostimulation

Grégoire Courtine, Marco Capogrosso, Beatrice Barra, Katie Zhi Zhuang

A system (10) for providing neuromodulation, especially neurostimulation, comprising - at least one neuromodulator (12) for neuromodulation of the cervical spinal cord, - at least one dorsal neuromodulation array (14) for providing neuromodulation to the c ...

2020

A versatile robotic platform for the design of natural, three-dimensional reaching and grasping tasks in monkeys

Aude Billard, Sophie Marie Marthe Wurth, Marion Aimée Geneviève Badi-Dubois, Silvestro Micera, Marco Capogrosso, Seyed Sina Mirrazavi Salehian, Sara Conti

Objective. Translational studies on motor control and neurological disorders require detailed monitoring of sensorimotor components of natural limb movements in relevant animal models. However, available experimental tools do not provide a sufficiently ric ...

IOP PUBLISHING LTD2020

Automatic clustering of spinal reflexes evoked by epidural electrical stimulation of the cervical spinal cord in non-human primates

Giuseppe Schiavone, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Sara Conti, Beatrice Barra, Katie Zhi Zhuang, Jocelyne Bloch

Epidural electrical stimulation of the spinal cord elicits motor responses by recruiting large sensory afferents in the posterior roots. Divergence of excitatory inputs provided by these fibers generates a variety of shapes, latencies and amplitudes in the ...

2019

Microneurography as a tool to develop decoding algorithms for peripheral neuro-controlled hand prostheses

Silvestro Micera, Stanisa Raspopovic, Marco Capogrosso, Francesco Maria Petrini, Jacopo Rigosa, Alessandra Pampaloni, Beatrice Barra

Background:The usability of dexterous hand prostheses is still hampered by the lack of natural and effective control strategies. A decoding strategy based on the process-ing of descending efferent neural signals recorded using peripheral neural interfaces ...

2019

A system for planning and/or providing neuromodulation

Vincent Delattre, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian

The present invention relates to a system for planning and/or providing neuromodulation (10), especially neurostimulation, comprising - a stimulation related basic data storage module (28) for storing the stimulation related basic data, - a stimulation rel ...

2019

A system for planning and/or providing neuromodulation

Vincent Delattre, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian

The present invention relates to a system for planning and/or providing neuromodulation (10), especially neurostimulation, comprising: - first data input module (26) for stimulation related basic data, - a stimulation related basic data storage module (28) ...

2019

System for planning and/or providing neuromodulation, especially neurostimulation

Vincent Delattre, Grégoire Courtine, Miroslav Caban, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian

The present invention relates system for planning and/or providing neuromodulation (10), especially neurostimulation, comprising - a neurostimulator (24) comprising a least one electrode (22), - functional mapping module (38) configured and arranged such t ...

2019

A system for planning and/or providing neurostimulation for a patient

Vincent Delattre, Tomislav Milekovic, Grégoire Courtine, Marco Capogrosso, Flavio Raschella, Fabien Bertrand Paul Wagner

The present invention relates to a system (10) for planning and/or providing neurostimulation for a patient, comprising: - a pathological spinal cord map storage module (48) for storing at least one pathological spinal cord map (49) describing the activati ...

2019

System for selective spatiotemporal stimulation of the spinal cord

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Marco Capogrosso, Jocelyne Bloch

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject ...

2019

Selective Recruitment of Arm Motoneurons in Nonhuman Primates Using Epidural Electrical Stimulation of the Cervical Spinal Cord

Giuseppe Schiavone, Camille Roux, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Beatrice Barra, Jocelyne Bloch

Recovery of reaching and grasping ability is the priority for people with cervical spinal cord injury (SCI). Epidural electrical stimulation (EES) has shown promising results in improving motor control after SCI in various animal models and in humans. Nota ...

2018

Closed-loop control of trunk posture improves locomotion through the regulation of leg proprioceptive feedback after spinal cord injury

Jenifer Cléa Miehlbradt, Sophie Marie Marthe Wurth, Silvestro Micera, Grégoire Courtine, Joachim von Zitzewitz, Eduardo Martin Moraud, Emanuele Formento, Marco Capogrosso

Nature Research2018

Targeted neurotechnology restores walking in humans with spinal cord injury

Vincent Delattre, Camille Georgette Marie Le Goff-Mignardot, Salif Axel Komi, Elvira Pirondini, Roman Heimgartner, Grégoire Courtine, Miroslav Caban, Joachim von Zitzewitz, Marco Capogrosso, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Karen Minassian, Esra Neufeld, Jocelyne Bloch, Ismael Seanez Gonzalez, Hendrik Lambert, Anne Marie Lucienne Watrin, Perrine Seguin, Laura Ann McCracken, Molywan Vat, Edoardo Paoles

2018

Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Beatrice Barra, Jocelyne Bloch, Xiaoyang Kang

IEEE2018

Two-phase calibration of a neuroprosthetic system

Tomislav Milekovic, Jérôme Gandar, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, Fabien Bertrand Paul Wagner

Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a ...

2018