Publications by Shoubhik Das | EPFL Graph Search

N-formylation and N-methylation of amines using metal-free N-heterocyclic carbene catalysts and CO2 as carbon source

Paul Joseph Dyson, Felix Daniel Bobbink, Shoubhik Das

N-formylation and N-methylation of amines are important reactions that are used to produce a wide range of key intermediates and compounds. This protocol describes the environmentally benign N-formylation and N-methylation of primary and secondary amines u ...

Nature Publishing Group2017

Delineating the Mechanism of Ionic Liquids in the Synthesis of Quinazoline-2,4(1H,3H)-dione from 2-Aminobenzonitrile and CO2

Gabor Laurenczy, Paul Joseph Dyson, Shoubhik Das, Sami Manoubi Armand Chamam, Martin Hulla

Ionic liquids (ILs) are versatile solvents and catalysts for the synthesis of quinazoline-2,4-dione from 2-aminobenzonitrile and CO2. However, the role of the IL in this reaction is poorly understood. Consequently, we investigated this reaction and showed ...

Wiley-Blackwell2017

Thiazolium carbene catalysts for the fixation of CO2 onto amines

Paul Joseph Dyson, Safak Bulut, Felix Daniel Bobbink, Mylène Soudani, Shoubhik Das

The catalytic N-formylation and N-methylation of amines using CO2 as the carbon source represents a facile and sustainable approach for the synthesis of pharmaceuticals and natural products. Herein, we describe highly effective and inexpensive thiazolium c ...

Royal Society of Chemistry2016

Synthesis of cyclic carbonates from diols and CO2 catalyzed by carbenes

Paul Joseph Dyson, Felix Daniel Bobbink, Shoubhik Das, Martin Hulla, Weronika Gruszka

The synthesis of cyclic carbonates from epoxides and CO2 is a well-established reaction, whereas the synthesis of cyclic carbonates from diols and CO2 is considerably more challenging, and few efficient catalysts are available. Here, we describe heterocycl ...

Royal Society of Chemistry2016

Carbon Dioxide Based N-Formylation of Amines Catalyzed by Fluoride and Hydroxide Anions

Paul Joseph Dyson, Felix Daniel Bobbink, Shoubhik Das, Martin Hulla

We described herein a simple approach for N-formylation with CO2 and hydrosilane reducing agents. Fluoride and hydroxide salts efficiently catalyzed the reaction, principally through activation of the hydrosilanes, which led to hydrosilane reactivities com ...

Wiley-VCH Verlag2016

Functionalized Ionic (Poly)Styrenes and their Application as Catalysts in the Cycloaddition of CO2 to Epoxides

Rosario Scopelliti, Paul Joseph Dyson, Zhaofu Fei, Felix Daniel Bobbink, Shoubhik Das

Valorization of CO2, an abundant C(1) synthon, into platform chemicals is of growing interest. In this context, a key reaction is the cycloaddition of CO2 to epoxides to form carbonates (CCE). A series of organocatalysts for this reaction, based on imidazo ...

Wiley-Blackwell2016

A Rhodium Nanoparticle-Lewis Acidic Ionic Liquid Catalyst for the Chemoselective Reduction of Heteroarenes

Paul Joseph Dyson, Ismail Akçok, Alena Karakulina, Shoubhik Das, Aswin Gopakumar, Bastien Lucas Roulier

We describe a catalytic system composed of rhodium nanoparticles immobilized in a Lewis acidic ionic liquid. The combined system catalyzes the hydrogenation of quinolines, pyridines, benzofurans, and furan to access the corresponding heterocycles, importan ...

Wiley-VCH Verlag GmbH2016

Soft Approaches to CO2 Activation

Paul Joseph Dyson, Felix Daniel Bobbink, Shoubhik Das, Aswin Gopakumar

The utilization of CO2 as a C1 synthon is becoming increasingly important as a feedstock derived from carbon capture and storage technologies. Herein, we describe some of our recent research on carbon dioxide valorization, notably, using organocatalysts to ...

Swiss Chemical Soc2015

Metal-Free Catalyst for the Chemoselective Methylation of Amines Using Carbon Dioxide as a Carbon Source

Gabor Laurenczy, Paul Joseph Dyson, Felix Daniel Bobbink, Shoubhik Das

N-methylation of amines is an important step in the synthesis of many pharmaceuticals and has been widely applied in the preparation of other key intermediates and chemicals. Therefore, the development of efficient methylation methods has attracted conside ...

Wiley-VCH Verlag GmbH2014