Publications by Mark Andrew Anderson

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Léonie Asboth, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Nicolas Hankov, Katia Galan, Robin Jonathan Demesmaeker, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Matthieu Pierre Gautier, Jimmy James Ravier, Thomas Haynes Hutson, Viviana Aureli

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

Neurotrauma treatment

Bernard Schneider, Grégoire Courtine, Mark Andrew Anderson, Jordan Squair

The invention provides pharmaceutical compositions, combinations and vectors, such as expression vectors, as well as use thereof in a method for central nervous system repair after neurotrauma, such as spinal cord injury (SCI) or stroke and in a method for ...

2024

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Bernard Schneider, Grégoire Courtine, Quentin Barraud, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Katia Galan, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Marco Milano, Jordan Squair, Matthieu Pierre Gautier, Anna Lasne, Thomas Haynes Hutson, Steven Lee Ceto, Michael Alexander Skinnider

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

American Association for the Advancement of Science2023

Natural and targeted circuit reorganization after spinal cord injury

Grégoire Courtine, Quentin Barraud, Mark Andrew Anderson, Jocelyne Bloch, Claudia Kathe, Jordan Squair, Matthieu Pierre Gautier, Thomas Haynes Hutson

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. ...

NATURE PORTFOLIO2022

Engineering spinal cord repair

Grégoire Courtine, Mark Andrew Anderson, Michael V. Sofroniew, Jordan Squair, Matthieu Pierre Gautier

Neurological damage caused by spinal cord injury in humans has been observed for over three thousand years and impacts the lives of several hundred thousand people worldwide. Despite this prevalence and its associated consequences, there is no treatment to ...

CURRENT BIOLOGY LTD2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Jérôme Gandar, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Salif Axel Komi, Stéphanie Lacour, Arnaud Bichat, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Eduardo Martin Moraud, Marco Capogrosso, Mark Andrew Anderson, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Ileana Ozana Jelescu, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Laura Ann McCracken, Matthieu Pierre Gautier, Loïs Thomas Romain Mahe, Jimmy James Ravier

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Targeting Central Nervous System Regeneration with Cell Type Specificity

Mark Andrew Anderson

2021

Cell type prioritization in single-cell data

Grégoire Courtine, Quentin Barraud, Mark Andrew Anderson, Claudia Kathe, Marco Milano, Jordan Squair, Matthieu Pierre Gautier, Gioele La Manno, Thomas Haynes Hutson, Michael Alexander Skinnider

The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis. ...

NATURE PUBLISHING GROUP2021

Confronting false discoveries in single-cell differential expression

Grégoire Courtine, Quentin Barraud, Mark Andrew Anderson, Claudia Kathe, Nicholas David James, Jordan Squair, Matthieu Pierre Gautier, Gioele La Manno, Thomas Haynes Hutson, Rémi Bernard René Hudelle, Michael Alexander Skinnider

Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries. ...

Nature Portfolio2021

Required growth facilitators propel axon regeneration across complete spinal cord injury

Sabry Leonardo Barlatey, Grégoire Courtine, Cheng Wang, Mark Andrew Anderson, Michael V. Sofroniew, Zhigang He, Nicholas David James

Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1,2,3, but efficient reversal of this regrowth failure ...

2018

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Bernard Schneider, Léonie Asboth, Grégoire Courtine, Janine Beauparlant, Lucia Florinda Friedli Wittler, Selin Anil, Quentin Barraud, Cristina Martinez Gonzalez, Julie Kreider, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Galyna Pidpruzhnykova, Elodie Rey, Polina Shkorbatova

Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished ...

2018

Influencing axon regeneration after spinal cord injury

Mark Andrew Anderson

Spinal cord injury (SCI) results in a severing of axonal connections that leads to permanent sensorimotor deficits. In cases of incomplete injury, rehabilitation paradigms have been reported to be successful in improving behavioral outcome in humans with S ...

EPFL2017