Publications by Georgios Fengos

Symbolic kinetic models in python (SKiMpy): intuitive modeling of large-scale biological kinetic models

Vassily Hatzimanikatis, Georgios Fengos, Pierre Guy Rémy Salvy, Daniel Robert Weilandt, Zhaleh Hosseini, Maria Masid Barcon

Motivation: Large-scale kinetic models are an invaluable tool to understand the dynamic and adaptive responses of biological systems. The development and application of these models have been limited by the availability of computational tools to build and ...

OXFORD UNIV PRESS2022

The effects of model complexity and size on metabolic flux distribution and control: case study in Escherichia coli

Vassily Hatzimanikatis, Georgios Fengos, Tuure Eelis Hameri

Background Significant efforts have been made in building large-scale kinetic models of cellular metabolism in the past two decades. However, most kinetic models published to date, remain focused around central carbon pathways or are built around ad hoc re ...

BMC2021

MEMOTE for standardized genome-scale metabolic model testing

Jens Nielsen, Vassily Hatzimanikatis, Cheng Zhang, Meriç Ataman, Georgios Fengos, Ali Kaafarani

NATURE PUBLISHING GROUP2020

Kinetic models of metabolism that consider alternative steady-state solutions of intracellular fluxes and concentrations

Ljubisa Miskovic, Vassily Hatzimanikatis, Meriç Ataman, Georgios Fengos, Tuure Eelis Hameri

Large-scale kinetic models are used for designing, predicting, and understanding the metabolic responses of living cells. Kinetic models are particularly attractive for the biosynthesis of target molecules in cells as they are typically better than other t ...

2019

pyTFA and matTFA: a Python package and a Matlab toolbox for Thermodynamics-based Flux Analysis

Vassily Hatzimanikatis, Keng Cher Soh, Meriç Ataman, Georgios Fengos, Pierre Guy Rémy Salvy

Summary: pyTFA and matTFA are the first published implementations of the original TFA paper. Specifically, they include explicit formulation of Gibbs energies and metabolite concentrations, which enables straightforward integration of metabolite concentrat ...

2018

redGEM: Systematic reduction and analysis of genome-scale metabolic reconstructions for development of consistent core metabolic models

Vassily Hatzimanikatis, Meriç Ataman, Daniel Federico Hernandez Gardiol, Georgios Fengos

Genome-scale metabolic reconstructions have proven to be valuable resources in enhancing our understanding of metabolic networks as they encapsulate all known metabolic capabilities of the organisms from genes to proteins to their functions. However the co ...

2017

Rites of passage: requirements and standards for building kinetic models of metabolic phenotypes

Ljubisa Miskovic, Vassily Hatzimanikatis, Milenko Tokic, Georgios Fengos

The overarching ambition of kinetic metabolic modeling is to capture the dynamic behavior of metabolism to such an extent that systems and synthetic biology strategies can reliably be tested in silico. The lack of kinetic data hampers the development of ki ...

Elsevier2015