Publications by Christian Hammer

The influence of human genetic variation on Epstein–Barr virus sequence diversity

Jacques Fellay, Christian Hammer, Dylan Lawless, Olivier Noël Marie Naret, Sina Rüeger

Epstein–Barr virus (EBV) is one of the most common viruses latently infecting humans. Little is known about the impact of human genetic variation on the large inter-individual differences observed in response to EBV infection. To search for a potential imp ...

Nature Research2021

Human genomics of the humoral immune response against polyomaviruses

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Hammer, Petar Scepanovic, Christian Axel Wandall Thorball, Olivier Noël Marie Naret, Zhi Ming Xu

Human polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of the humoral immune response against polyomaviruses, we performed genome-wide association studies and meta ...

OXFORD UNIV PRESS2021

Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma

Jacques Fellay, Christian Hammer, Christian Axel Wandall Thorball

Human immunodeficiency virus (HIV) infection is associated with an increased risk of non-Hodgkin lymphoma (NHL). Even in the era of suppressive antiretroviral treatment, HIV-infected individuals remain at higher risk of developing NHL compared to the gener ...

FERRATA STORTI FOUNDATION2021

Human genomics of the humoral response against polyomaviruses

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Hammer, Petar Scepanovic, Christian Axel Wandall Thorball, Zhi Ming Xu

SPRINGERNATURE2020

Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy

Thierry Buclin, Monia Guidi, Jacques Fellay, Christian Hammer, Christian Axel Wandall Thorball

Objective. There is limited data on abdominal obesity and the influence of genetics on weight change after ant iretroviral therapy (ART) initiation. We assessed body mass index (BMI) and waist hip ration (WHR) change over time in the Swiss HIV Cohort study ...

OXFORD UNIV PRESS INC2020

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

Jacques Fellay, Christian Hammer, Daniel Sauter

Many viral pathogens target innate sensing cascades and/or cellular transcription factors to suppress antiviral immune responses. Here, we show that the accessory viral protein U (Vpu) of HIV-1 exerts broad immunosuppressive effects by inhibiting activatio ...

2019

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Hammer, Petar Scepanovic

Background The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Interieur Consortium, a total ...

2019

Genome-to-genome analysis of Epstein-Barr virus infection

Jacques Fellay, Christian Hammer

NATURE PUBLISHING GROUP2019

Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients

Samira Asgari, Jacques Fellay, Christian Hammer, Petar Scepanovic, Nimisha Chaturvedi

Acute liver failure (ALF) or fulminant hepatitis is a rare, yet severe outcome of infection with hepatitis B virus (HBV) that carries a high mortality rate. The occurrence of a life-threatening condition upon infection with a prevalent virus in individuals ...

2019

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Hammer, Petar Scepanovic, Nimisha Chaturvedi, Christian Axel Wandall Thorball

2018

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Jacques Fellay, Christian Hammer, Petar Scepanovic

2018

Correcting for Population Stratification Reduces False Positive and False Negative Results in Joint Analyses of Host and Pathogen Genomes

Jacques Fellay, Istvan Bartha, Christian Hammer, Nimisha Chaturvedi, Olivier Noël Marie Naret

2018

Memory B Cells Activate Brain-Homing, Autoreactive CD4(+) T Cells in Multiple Sclerosis

Christian Hammer, Jian Wang

Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic, particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic factors contribute to generating an autoreactive CD4(+) T cell repertoire is no ...

CELL PRESS2018

The Serotonin receptor 3E subunit variant HTR3E c.*76G> A is confirmed as a risk factor for IBS-D in females

Patrik Willi Hoffmann, Christian Hammer

WILEY2018

B - T cell interactions activate and maintain brain-homing T cells in multiple sclerosis

Christian Hammer, Jian Wang

SAGE PUBLICATIONS LTD2018

Severe viral respiratory infections in children with IFIH1 loss-of-function mutations

Thomas Junier, Amalio Telenti, Samira Asgari, Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren, Christian Hammer

Viral respiratory infections are usually mild and self-limiting; still they exceptionally result in life-threatening infections in previously healthy children. To investigate a potential genetic cause, we recruited 120 previously healthy children requiring ...

Natl Acad Sciences2017

A functional SNP of the serotonin transporter gene promoter is associated with IBS

Christian Hammer

Wiley2017

A functional variant in the alternative serotonin transporter gene SLC6A4 promoter P2 has a potential impact on irritable bowel syndrome

Christian Hammer

Wiley-Blackwell2016

Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses

Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren, Christian Hammer

The magnitude of the human antibody response to viral antigens is highly variable. To explore the human genetic contribution to this variability, we performed genome-wide association studies of the immunoglobulin G response to 14 pathogenic viruses in 2,36 ...

Cell Press2015

Performance of Serum microRNAs-122,-192 and-21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis

Christian Hammer

Objectives Liver biopsies are the current gold standard in non-alcoholic steatohepatitis (NASH) diagnosis. Their invasive nature, however, still carries an increased risk for patients' health. The development of non-invasive diagnostic tools to differentia ...

Public Library of Science2015