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Peiling Luan

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Related publications (6)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

Johan Auwerx, Maroun Bou Sleiman, Peiling Luan, Davide D'Amico, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Sébastien Robert Victor Herzig, Tanes Imamura de Lima, Qi Wang, Barbara Moreira Crisol

Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle upon aging and that both genetic a ...

2022

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

Johan Auwerx, Peiling Luan, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Ludger Jan Elzuë Goeminne, Tanes Imamura de Lima

Duchenne muscular dystrophy (DMD), the most common muscular dystrophy, is a severe muscle disorder, causing muscle weakness, loss of independence, and premature death. Here, we establish the link between sphingolipids and muscular dystrophy. Transcripts of ...

2022

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

Johan Auwerx, Pénélope Andreux, Peiling Luan, Hao Li, Davide D'Amico, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Tanes Imamura de Lima

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite advances in genetic and pharmacological disease-modifying treatments, its management remains a major challenge. Mitochondrial dysfunction contributes to DMD, yet the mecha ...

AMER ASSOC ADVANCEMENT SCIENCE2021