Publications by Katia Galan | EPFL Graph Search

A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation

Florian Dylan Fallegger, Stéphanie Lacour, Silvestro Micera, Katia Galan, Ivan Furfaro, Valentina Marie Paggi, Olivier Didier Christian Rizzo

Background: Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in discrete circular sizes, complications ...

2024

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Léonie Asboth, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Nicolas Hankov, Katia Galan, Robin Jonathan Demesmaeker, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Matthieu Pierre Gautier, Jimmy James Ravier, Thomas Haynes Hutson, Viviana Aureli

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Bernard Schneider, Grégoire Courtine, Quentin Barraud, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Katia Galan, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Marco Milano, Jordan Squair, Matthieu Pierre Gautier, Anna Lasne, Thomas Haynes Hutson, Steven Lee Ceto, Michael Alexander Skinnider

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

American Association for the Advancement of Science2023

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Tomislav Milekovic, Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Katia Galan, Jocelyne Bloch, Nicholas David James

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

The neurons that restore walking after paralysis

Léonie Asboth, Salif Axel Komi, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Laetitia Danielle Philippine Baud, Katia Galan, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Matthieu Pierre Gautier, Kyungjin Kim, Thomas Haynes Hutson, Steven Lee Ceto

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Epineural optogenetic activation of nociceptors initiates and amplifies inflammation

Frédéric Pierre Gérald Michoud, Stéphanie Lacour, Katia Galan, Ivan Furfaro, Outman Akouissi

Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation(1,2), but whether nociceptors also interact with the immune system remains poorly understo ...

NATURE RESEARCH2020

Diverse Long-Range Axonal Projections of Excitatory Layer 2/3 Neurons in Mouse Barrel Cortex

Carl Petersen, Aurélie Pala, Sylvain Crochet, Takayuki Yamashita, Katia Galan

2018

Reward-Based Learning Drives Rapid Sensory Signals in Medial Prefrontal Cortex and Dorsal Hippocampus Necessary for Goal-Directed Behavior

Carl Petersen, Sylvain Crochet, Pierre François Philippe Le Merre, Eloïse Ludivine Charrière, Katia Galan, Vahid Esmaeili

2018

Movement Initiation Signals in Mouse Whisker Motor Cortex

Carl Petersen, Sylvain Crochet, Varun Sreenivasan, Taro Kiritani, Katia Galan, Vahid Esmaeili

Frontal cortex plays a central role in the control of voluntary movements, which are typically guided by sensory input. Here, we investigate the function of mouse whisker primary motor cortex (wM1), a frontal region defined by dense innervation from whiske ...

Cell Press2016

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Katia Galan

Pharmacological treatments targeting CXC chemokines and the associated neutrophil activation and recruitment into atherosclerotic plaques hold promise for treating cardiovascular disorders. Therefore, we investigated whether FK866, a nicotinamide phosphori ...

Schattauer2014

Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Fabiana Pereira Da Costa Fraga, Katia Galan

Angiotensin (Ang)-(1-7), acting through the receptor Mas, has athero-protective effects; however, its role on plaque vulnerability has been poorly studied. Here, we investigated the expression of the renin-angiotensin system (RAS) components in stable and ...

Schattauer2014

Treatment with Evasin-3 reduces atherosclerotic vulnerability for ischemic stroke, but not brain injury in mice

Nikolaos Stergiopoulos, Luciano Dos Santos Aggum Capettini, Danielle Gomes Passos Silva, Jean-Christophe Copin, Katia Galan

Neutrophilic inflammation might have a pathophysiological role in both carotid plaque rupture and ischemic stroke injury. Here, we investigated the potential benefits of the CXC chemokine-binding protein Evasin-3, which potently inhibits chemokine bioactiv ...

Nature Publishing Group2013

The selective pharmacologic inhibition of CXC chemokines is associated with an improvement of histological features of vulnerability in mouse atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Katia Galan

Wiley-Blackwell2013

The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Katia Galan

The activation of cannabinoid receptor type 2 (CB2)-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB2 pharmacologi ...

Oxford University Press2012

Treatment with chemokine-binding protein Evasin-3 reduces atherosclerotic vulnerability for ischemic stroke in mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Katia Galan

Academic Press Ltd- Elsevier Science Ltd2012