Publications by Nimisha Chaturvedi

Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure

Sofosbuvir is a common therapy in hepatitis C virus infection, which targets the NS5B polymerase. Here, Smith et al. analyze the association between whole genome HCV polymorphisms and sofosbuvir treatment failure and identify three common polymorphisms pre ...

Nature Portfolio2021

Whole-exome Sequencing for the Identification of Rare Variants in Primary Immunodeficiency Genes in Children With Sepsis: A Prospective, Population-based Cohort Study

Samira Asgari, Jacques Fellay, Nimisha Chaturvedi, Christian Axel Wandall Thorball, Alessandro Borghesi

Background. The role of primary immunodeficiencies (PID) in susceptibility to sepsis remains unknown. It is unclear whether children with sepsis benefit from genetic investigations. We hypothesized that sepsis may represent the first manifestation of under ...

OXFORD UNIV PRESS INC2020

Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes

Jacques Fellay, Nimisha Chaturvedi

Genetic polymorphism in the interferon lambda (IFN-lambda) region is associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to interferon-based treatment. Here, we evaluate associations between IFN-l polymorphism and HCV va ...

2019

HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control

Jacques Fellay, Paul Jack Mc Laren, Nimisha Chaturvedi

Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I molecules has repeatedly been associated with HIV-1 control and progression to AIDS, accounting for up to 12% of the variation in HIV-1 set point viral load (spVL). This ...

National Academy of Sciences2019

Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients

Samira Asgari, Jacques Fellay, Christian Hammer, Petar Scepanovic, Nimisha Chaturvedi

Acute liver failure (ALF) or fulminant hepatitis is a rare, yet severe outcome of infection with hepatitis B virus (HBV) that carries a high mortality rate. The occurrence of a life-threatening condition upon infection with a prevalent virus in individuals ...

2019

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Hammer, Petar Scepanovic, Nimisha Chaturvedi, Christian Axel Wandall Thorball

2018

Correcting for Population Stratification Reduces False Positive and False Negative Results in Joint Analyses of Host and Pathogen Genomes

Jacques Fellay, Istvan Bartha, Christian Hammer, Nimisha Chaturvedi, Olivier Noël Marie Naret

2018

Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives

Jacques Fellay, Nimisha Chaturvedi

Tuberculosis is an ancient human disease, estimated to have originated and evolved over thousands of years alongside modern human populations. Despite considerable advances in disease control, tuberculosis remains one of the world's deadliest communicable ...

2018

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

David Smith, Jacques Fellay, Istvan Bartha, Nimisha Chaturvedi

Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. Here we use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 5 ...

Nature Publishing Group2017

Multiple HCV Amino Acid Variants Associate with Interferon Lambda Polymorphism in Genotype 1a, 1b and 3a Infections

Jacques Fellay, Nimisha Chaturvedi

Wiley-Blackwell2016

The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome

Amalio Telenti, Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren, Nimisha Chaturvedi

Sequencing projects have identified large numbers of rare stop-gain and frameshift variants in the human genome. As most of these are observed in the heterozygous state, they test a gene's tolerance to haploinsufficiency and dominant loss of function. We a ...

Public Library Science2015