Publications by Giulia Fonti | EPFL Graph Search

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Patrick Alain Sandoz, Florence Pojer, Matteo Dal Peraro, Sylvia Ho, Martina Audagnotto, Giulia Fonti, Maria Josefina Marcaida Lopez, Muhammad Umair Anwar, Francisco De Magalhães Sarmento R De Mesquita

Acyl protein thioesterase APT2 interacts with membranes via its charged beta-tongue, becomes palmitoylated by ZDHHC3/7 and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation. ...

NATURE RESEARCH2021

CLoNe: automated clustering based on local density neighborhoods for application to biomolecular structural ensembles

Matteo Dal Peraro, Sylvain Träger, Martina Audagnotto, Giorgio Elikem Tamo, Deniz Aydin, Giulia Fonti

Motivation: Proteins are intrinsically dynamic entities. Flexibility sampling methods, such as molecular dynamics or those arising from integrative modeling strategies, are now commonplace and enable the study of molecular conformational landscapes in many ...

OXFORD UNIV PRESS2021

KAP1 is an antiparallel dimer with a functional asymmetry

Didier Trono, Davide Demurtas, Matteo Dal Peraro, Louise Catherine Bryan, Beat Fierz, Pierre-Yves Joseph Laurent Helleboid, Alexandra Styliani Kalantzi, Giulia Fonti, Maria Josefina Marcaida Lopez

KAP1 (KRAB domain-associated protein 1) plays a fundamental role in regulating gene expression in mammalian cells by recruiting different transcription factors and altering the chromatin state. In doing so, KAP1 acts both as a platform for macromolecular i ...

Life Science Alliance, LLC2019

Structural and functional characterisation of the KRAB-domain associated protein 1

Giulia Fonti

KAP1 (KRAB-domain associated protein 1) plays a fundamental role in regulating gene expression in mammalian cells by recruiting different transcription factors and altering the chromatin state. In doing so, KAP1 acts both as a platform for macromolecular i ...

EPFL2019

Assessment of data-assisted prediction by inclusion of crosslinking/mass-spectrometry and small angle X-ray scattering data in the 12(th) Critical Assessment of protein Structure Prediction experiment

Matteo Dal Peraro, Luciano Andres Abriata, Giorgio Elikem Tamo, Giulia Fonti

2018

A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria

John McKinney, Florence Pojer, Matteo Dal Peraro, Tarun Chopra, Paul Murima, Giulia Fonti

Fatty acid metabolism is an important feature of the pathogenicity of Mycobacterium tuberculosis during infection. Consumption of fatty acids requires regulation of carbon flux bifurcation between the oxidative TCA cycle and the glyoxylate shunt. In Escher ...

Nature Publishing Group2016