Publications by Magda Zachara | EPFL Graph Search

A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion

Bart Deplancke, Pernille Yde Rainer, Radiana Ferrero, Julie Marie Russeil, Magda Zachara, Daniel Alpern, Vincent Roland Julien Gardeux, Jörn Pezoldt, Guido Van Mierlo

Although several mouse and human adipose SVF cellular subpopulations have by now been identified, we still lack an understanding of the cellular and functional variability of adipose stem and progenitor cell (ASPC) populations across human fat depots. To a ...

Cell Press2024

Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non- and anti-adipogenic in age-dependent manner

Bart Deplancke, Pernille Yde Rainer, Radiana Ferrero, Julie Marie Russeil, Horia Hashimi, Magda Zachara, Daniel Alpern, Maria Litovchenko

Adipose stem and precursor cells (ASPCs) give rise to adipocytes and determine the composition and plasticity of adipose tissue. Recently, several studies have demonstrated that ASPCs partition into at least three distinct cell subpopulations, including th ...

WILEY2022

Live-seq enables temporal transcriptomic recording of single cells

Bart Deplancke, Pernille Yde Rainer, Riccardo Dainese, Wanze Chen, Magda Zachara, Vincent Roland Julien Gardeux, Wouter Saelens, Orane Josiane Guillaume-Gentil

Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize cellular heterogeneity(1). However, scRNA-seq requires lysing cells, which impedes further molecular or functional analyses on the same cells. Here, we established Liv ...

NATURE PORTFOLIO2022

A single-cell-based identification and characterisation of Aregs, an inhibitory subpopulation of adipose stem and precursor cells

Magda Zachara

Adipose tissue is an essential element in energy conservation mechanisms. Its unique plasticity is driven by the ability of adipocytes to accumulate and liberate lipids as a function of the energetic status of the organism. Given the recent rise in the glo ...

EPFL2020

A stromal cell population that inhibits adipogenesis in mammalian fat depots

Bart Deplancke, Petra Catalina Schwalie, Julie Marie Russeil, Magda Zachara, Daniel Alpern

2018

A systems perspective on brown adipogenesis and metabolic activation

Bart Deplancke, Rachana Narendra Pradhan, Magda Zachara

Brown adipocytes regulate energy expenditure via mitochondrial uncoupling. This makes these fat cells attractive therapeutic targets to tackle the burgeoning issue of obesity, which itself is coupled to insulin resistance, type 2 diabetes, cardiovascular a ...

Wiley-Blackwell2017