Publications by Peyman Karami | EPFL Graph Search

Cartilage Repair: Promise of Adhesive Orthopedic Hydrogels

Dominique Pioletti, Lee Ann Laurent-Applegate, Peyman Karami

Cartilage repair remains a major challenge in human orthopedic medicine, necessitating the application of innovative strategies to overcome existing technical and clinical limitations. Adhesive hydrogels have emerged as promising candidates for cartilage r ...

MDPI2024

Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept

Dominique Pioletti, Nikolaos Stergiopoulos, Peyman Karami, Ece Uslu, Vijay Kumar Rana, Sokratis Anagnostopoulos

Tracheomalacia (TM) is a condition characterized by a weak tracheal cartilage and/or muscle, resulting in excessive collapse of the airway in the newborns. Current treatments including tracheal reconstruction, tracheoplasty, endo- and extra-luminal stents ...

CELL PRESS2023

Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Peyman Karami, Theofanis Stampoultzis, Yanheng Guo

Articular cartilage presents a mechanically sensitive tissue. Chondrocytes, the sole cell type residing in the tissue, perceive and react to physical cues as signals that significantly modulate their behavior. Hyaline cartilage is a connective tissue with ...

2023

Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Peyman Karami, Theofanis Stampoultzis, Yanheng Guo, Vijay Kumar Rana

Cartilage degeneration, typically viewed as an irreversible, vicious cycle, sees a significant reduction in two essential biophysical cues: the well-established hydrostatic pressure (HP) and the recently discovered transient temperature increase. Our study ...

Cell Press2023

A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Dominique Pioletti, Peyman Karami, Theofanis Stampoultzis, Yanheng Guo

The drive to develop cartilage implants for the treatment of major defects in the musculoskeletal sys-tem has resulted in a major research thrust towards developing biomaterial devices for cartilage repair. Investigational devices for the restoration of ar ...

ELSEVIER SCI LTD2023

Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Peyman Karami, Jian Wang, Yanheng Guo

During loading of viscoelastic tissues, part of the mechanical energy is transformed into heat that can locally increase the tissue temperature, a phenomenon known as self-heating. In the framework of mechanobiology, it has been accepted that cells react a ...

eLIFE SCIENCES PUBL LTD2022

NIR Light-Mediated Photocuring of Adhesive Hydrogels for Noninvasive Tissue Repair via Upconversion Optogenesis

Dominique Pioletti, Christophe Moser, Peyman Karami, Yanheng Guo, Vijay Kumar Rana, Antoine Vincent Boniface

The surgical treatments of injured soft tissues lead to further injury due to the use of sutures or the surgical routes, which need to be large enough to insert biomaterials for repair. In contrast, the use of low viscosity photopolymerizable hydrogels tha ...

American Chemical Society2022

An Injectable Family Of Soft Tissue Hydrogel Adhesives For Knee Applications

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser, Céline Samira Wyss, Peyman Karami

MARY ANN LIEBERT, INC2022

Thoughts on cartilage tissue engineering: A 21st century perspective

Dominique Pioletti, Peyman Karami, Theofanis Stampoultzis

In mature individuals, hyaline cartilage demonstrates a poor intrinsic capacity for repair, thus even minor defects could result in progressive degeneration, impeding quality of life. Although numerous attempts have been made over the past years for the ad ...

2021

An Intrinsically-Adhesive Family of Injectable and Photo-Curable Hydrogels with Functional Physicochemical Performance for Regenerative Medicine

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser, Céline Samira Wyss, Naser Nasrollahzadeh Mamaghani, Peyman Karami

Attaching hydrogels to soft internal tissues is crucial for the development of various biomedical devices. Tough sticky hydrogel patches present high adhesion, yet with lack of injectability and the need for treatment of contacting surface. On the contrary ...

WILEY-V C H VERLAG GMBH2021

Design and Development of Injectable, Tough and Intrinsically-Adhesive Hydrogels for Biomedical Applications

Peyman Karami

Despite the development of hydrogels with a wide range of mechanical properties, insufficient adhesion between these materials and biological surfaces limits their use in the biomedical applications. Most recent advancements in highly adhesive hydrogel sys ...

EPFL2021

Silk granular hydrogels self-reinforced with regenerated silk fibroin fibers

Dominique Pioletti, Pierre-Etienne Bourban, Céline Samira Wyss, Peyman Karami, Adrien Julien Demongeot

Granular hydrogels with high stability, strength, and toughness are laborious to develop. Post-curing is often employed to bind microgels chemically and enhance mechanical properties. Here a unique strategy was investigated to maintain microgels together w ...

2021

Hybrid granular hydrogels: combining composites and microgels for extended ranges of material properties

Dominique Pioletti, Pierre-Etienne Bourban, Céline Samira Wyss, Peyman Karami

Developing hydrogels with optimal properties for specific applications is challenging as most of these properties, such as toughness, stiffness, swelling or deformability, are interrelated. The improvement of one property usually comes at the cost of anoth ...

2020

Cross-linkable polymer, hydrogel, and method of preparation thereof

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser, Céline Samira Wyss, Peyman Karami

The invention relates to a cross-linkable polymer comprising a base polymer comprising functional groups at least some of which have been reacted with a first organic molecule comprising a cross-linkable unit and with a second organic molecule capable of b ...

2020

Light-Activated, Bioadhesive, Poly(2-hydroxyethyl methacrylate) Brush Coatings

Dominique Pioletti, Harm-Anton Klok, Nariye Cavusoglu Ataman, Peyman Karami, Jian Wang

Rapid adhesion between tissue and synthetic materials is relevant to accelerate wound healing and to facilitate the integration of implantable medical devices. Most frequently, tissue adhesives are applied as a gel or a liquid formulation. This manuscript ...

American Chemical Society2020

Control of Dissipation Sources: A Central Aspect for Enhancing the Mechanical and Mechanobiological Performances of Hydrogels

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Peyman Karami

Development of mechanically durable and biologically inductive hydrogels is a major challenge for load-bearing applications such as engineered cartilage. Dissipative capacity of articular cartilage is central to its functional behavior when submitted to lo ...

2019

Cyclic loading of a cellulose/hydrogel composite increases its fracture strength

Dominique Pioletti, Pierre-Etienne Bourban, Céline Samira Wyss, Peyman Karami

The fracture properties of hydrogels which present similar characteristics to the Mullins effect is expected to decrease under repeated cyclic loading. Therefore, we assessed how cyclic loading affects the fracture behavior, the distribution of strain fiel ...

2018

Composite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser, Céline Samira Wyss, Martin Broome, Peyman Karami

Despite the development of hydrogels with high mechanical properties, insufficient adhesion between these materials and biological surfaces significantly limits their use in the biomedical field. By controlling toughening processes, we designed a composite ...

2018