Publications by Stefano Pagani

The role of computational methods in cardiovascular medicine: a narrative review

Alfio Quarteroni, Luca Dede', Christian Vergara, Stefano Pagani

Background and Objective: Computational models of the cardiovascular system allow for a detailed and quantitative investigation of both physiological and pathological conditions, thanks to their ability to combine clinical-possibly patient-specific-data wi ...

Ame Publishing Company2024

Learning the intrinsic dynamics of spatio-temporal processes through Latent Dynamics Networks

Alfio Quarteroni, Francesco Regazzoni, Stefano Pagani

Predicting the evolution of systems with spatio-temporal dynamics in response to external stimuli is essential for scientific progress. Traditional equations-based approaches leverage first principles through the numerical approximation of differential equ ...

Nature Portfolio2024

lifex-ep: a robust and efficient software for cardiac electrophysiology simulations

Alfio Quarteroni, Francesco Regazzoni, Marco Fedele, Stefano Pagani

Background: Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-performance computational tools. Despite the dedicated endeavors ...

BMC2023

PDE-Aware Deep Learning for Inverse Problems in Cardiac Electrophysiology

Alfio Quarteroni, Simone Deparis, Stefano Pagani, Riccardo Tenderini

In this work, we present a PDE-aware deep learning model for the numerical solution to the inverse problem of electrocardiography. The model both leverages data availability and exploits the knowledge of a physically based mathematical model, expressed by ...

2022

The role of mechano-electric feedbacks and hemodynamic coupling in scar-related ventricular tachycardia

Alfio Quarteroni, Luca Dede', Stefano Pagani

Mechano-electric feedbacks (MEFs), which model how mechanical stimuli are transduced into electrical signals, have received sparse investigation by considering electromechanical simulations in simplified scenarios. In this paper, we study the effects of di ...

2022

Data integration for the numerical simulation of cardiac electrophysiology

Alfio Quarteroni, Luca Dede', Andrea Manzoni, Stefano Pagani

The increasing availability of extensive and accurate clinical data is rapidly shaping cardiovascular care by improving the understanding of physiological and pathological mechanisms of the cardiovascular system and opening new frontiers in designing thera ...

WILEY2021

Outer loop and isthmus in ventricular tachycardia circuits: Characteristics and implications

Alfio Quarteroni, Luca Dede', Andrea Manzoni, Stefano Pagani

BACKGROUND The isthmus of ventricular tachycardia (VT) circuits has been extensively characterized. Few data exist regarding the contribution of the outer loop (OL) to the VT circuit. OBJECTIVE The purpose of this study was to characterize the electrophysi ...

2020

Accurate solution of Bayesian inverse uncertainty quantification problems combining reduced basis methods and reduction error models

Toni Mikael Lassila, Andrea Manzoni, Stefano Pagani

2016