Publications by Francesca Criscuolo

A wearable electrochemical sensing system for non-invasive monitoring of lithium drug in bipolar disorder

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Francesca Criscuolo

Lithium represents the main drug for the treatment of Bipolar Disorder (BD) as it acts as a mood stabilizer. However, because of its narrow therapeutic window, psychiatric patients are obliged to frequent tests in hospital to control their lithium blood co ...

2021

All-Solid-State Ion-Selective Electrodes: A Tutorial for Correct Practice

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Mandresy Ivan Ny Hanitra, Francesca Criscuolo

The research on ion-measuring devices has seen a rapid expansion in the last years as a consequence of the growing interest in wearable sensors for biofluids analysis and in portable devices for remote or in-line water and food quality monitoring. As a res ...

2021

Multi-ion-sensing emulator and multivariate calibration optimization by machine learning models

Giovanni De Micheli, Sandro Carrara, Mandresy Ivan Ny Hanitra, Francesca Criscuolo

One paramount challenge in multi-ion-sensing arises from ion interference that degrades the accuracy of sensor calibration. Machine learning models are here proposed to optimize such multivariate calibration. However, the acquisition of big experimental da ...

2021

Real-Time Multi-Ion-Monitoring Front-End With Interference Compensation by Multi-Output Support Vector Regressor

Giovanni De Micheli, Sandro Carrara, Mandresy Ivan Ny Hanitra, Francesca Criscuolo

Ion-sensors play a major role in physiology and healthcare monitoring since they are capable of continuously collecting biological data from body fluids. Nevertheless, ion interference from background electrolytes present in the sample is a paramount chall ...

2021

Multi-Channel Front-End for Electrochemical Sensing of Metabolites, Drugs, and Electrolytes

Giovanni De Micheli, Sandro Carrara, Nadezda Pankratova, Mandresy Ivan Ny Hanitra, Francesca Criscuolo

A multi-channel front-end for electrochemical sensing is presented. It consists of a multiplexed four-channel readout interface supporting amperometric, voltammetric, and potentiometric measurements. The electronic interface is co-designed according to the ...

2020

Wearable multifunctional sweat-sensing system for efficient healthcare monitoring

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Nicolò Oliva, Mandresy Ivan Ny Hanitra, Francesca Criscuolo, Simone Aiassa

Despite the huge expansion in recent years of sweat sensing and wearable technologies, several challenges are still open, including poor sample collection, separate sampling and analysis, low multi-sensing capabilities and materials toxicity. In this work, ...

2020

New Approach for Making Standard the Development of Biosensing Devices by a Modular Multi-Purpose Design

Sandro Carrara, Ioulia Tzouvadaki, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Francesca Criscuolo, Simone Aiassa

The fast widening of biosensing applications, such as healthcare, drug delivery, food, and military industries, is increasing the need for generality and compatibility among different sensors. To address this challenge, we present here an innovative approa ...

2020

Wearable multi-electrode platform for ion sensing

Francesca Criscuolo

With the growth of personalized medicine and e-Health, there has been an increasing interest in the development of accurate sensing systems able to support this healthcare revolution for both in- and off-hospital monitoring. Remote biosensing devices can d ...

EPFL2020

Continuous monitoring of propofol in human serum with fouling compensation by support vector classifier

Giovanni De Micheli, Sandro Carrara, Mandresy Ivan Ny Hanitra, Danilo Demarchi, Francesco Grassi, Francesca Criscuolo, Simone Aiassa, Tiberiu Totu, Gabriele Sandri

We present a new method for electrochemical sensing, which compensates the fouling effect of propofol through machine learning (ML) model. Direct and continuous monitoring of propofol is crucial in the development of automatic systems for control of drug i ...

Elsevier2020

Fast Procedures for the Electrodeposition of Platinum Nanostructures on Miniaturized Electrodes for Improved Ion Sensing

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Francesca Criscuolo

Nanostructured materials have attracted considerable interest over the last few decades to enhance sensing capabilities thanks to their unique properties and large surface area. In particular, noble metal nanostructures offer several advantages including h ...

2019

All-solid-state Reference Electrodes for analytical applications

Giovanni De Micheli, Sandro Carrara, Francesca Criscuolo

2019

Multi-Target Electrolyte Sensing Front-End for Wearable Physical Monitoring

Giovanni De Micheli, Sandro Carrara, Mandresy Ivan Ny Hanitra, Francesca Criscuolo

Wearable physiology is an expanding field, especially for sports applications that steadily require an accurate monitoring of the physical status of athletes. This work presents the co-design and the realization of an hardware front-end that enables multi- ...

IEEE2019

Flexible sweat sensors for non-invasive optimization of lithium dose in psychiatric disorders

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Francesca Criscuolo

Lithium is the main mood stabilizer in bipolar disorders and other psychiatric conditions. However, lithium levels in blood must be monitored frequently during therapies because of its narrow therapeutic range. For this reason the patients, whose quality o ...

IEEE2019

A novel electrochemical sensor for non-invasive monitoring of lithium levels in mood disorders

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Francesca Criscuolo

Lithium is the main drug for the treatment of mood disorders. Due to its narrow therapeutic window, Therapeutic Drug Monitoring (TDM) is a norm during therapy in order to avoid adverse effects. Consequently, patients are obliged to frequent check-ups in ho ...

2018

A Flexible Front-End for Wearable Electrochemical Sensing

Giovanni De Micheli, Sandro Carrara, Francesca Stradolini, Abuduwaili Tuoheti, Mandresy Ivan Ny Hanitra, Danilo Demarchi, Tugba Kilic, Francesca Criscuolo, Lucia Lobello

This work presents the design and the realization of a flexible front-end circuitry for electrochemical sensing with wearable devices. The hardware combines readout circuitry for amperometric and Open Circuit Potential (OCP) measurements. The sensing platf ...

IEEE2018

Highly-stable Li + ion-selective electrodes based on noble metal nanostructured layers as solid-contacts

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Francesca Stradolini, Francesca Criscuolo

Nowadays the development of stable and highly efficient Solid-Contact Ion-Selective Electrodes (SC-ISEs) attracts much attention in the research community because of the great expansion of portable analytical devices. In this work, we present highly stable ...

2018

Mixed gold and platinum nanostructured layers for all-solid-state ion sensors

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Danilo Demarchi, Francesca Criscuolo, Lucia Lobello

The great interest in portable and wearable monitoring systems has promoted in recent years a major expansion of all-solid-state Ion-Selective Electrodes (ISEs). Nanostructured Solid-Contacts (SCs) have shown a promising potential in order to eliminate the ...

IEEE2018

An electrochemical sensor for quantitative analysis of Rhesus D antibodies in blood

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Tugba Kilic, Francesca Criscuolo

The Hemolytic Disease of the Fetus and Newborn (HDFN), if untreated, can have severe consequences on baby’s health, eventually causing death. Prevention and diagnosis of pregnancies at risk of HDFN consists in quantitative analysis in hospital every 2-4 we ...

IEEE2017