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Mario Romani

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Related publications (9)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

Johan Auwerx, Hao Li, Mario Romani, Dohyun Park, Pirkka-Pekka Untamo Laurila, Changmyung Oh, Martin Rainer Wohlwend, Jean-David Horacio Morel, Xiaoxu Li, Ludger Jan Elzuë Goeminne, Tanes Imamura de Lima, Sandra Rodriguez Lopez, Barbara Moreira Crisol

Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their failure in aging remain poorly understood. Here, we showed that cer- amide biosynthesis controls the de ...

AMER ASSOC ADVANCEMENT SCIENCE2023

The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging

Johan Auwerx, Mario Romani, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Tanes Imamura de Lima

Skeletal muscle displays remarkable plasticity upon exercise and is also one of the organs most affected by aging. Despite robust evidence that aging is associated with loss of fast-twitch (type II) muscle fibers, the underlying mechanisms remain to be elu ...

2021

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

Loss of mitochondrial function and proteostasis typify aging and age-associated degenerative disorders such as Alzheimer's disease and muscle aging. To date, no cure or preventive measure is available to manage these conditions. Alterations of cellular pro ...

EPFL2021