Publications by Simon Borgognon

Regional specialization of movement encoding across the primate sensorimotor cortex

Tomislav Milekovic, Grégoire Courtine, Simon Borgognon, Jocelyne Bloch, Ismael Seanez Gonzalez, Nicolò Macellari

The process by which the cerebral cortex generates movements to achieve different tasks remains poorly understood. Here, we leveraged the rich repertoire of well-controlled primate locomotor behaviors to study how task-specific movements are encoded across ...

Springer Science and Business Media LLC2025

Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates

Simon Borgognon

The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...

SOC NEUROSCIENCE2023

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Tomislav Milekovic, Léonie Asboth, Camille Georgette Marie Le Goff-Mignardot, Giuseppe Schiavone, Elvira Pirondini, Stéphanie Lacour, Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, David Allenson Borton, Jean François Pierre Laurens, Jean-Baptiste Mignardot, Flavio Raschella, Robin Jonathan Demesmaeker, Simon Borgognon, Jocelyne Bloch, Shiqi Sun, Sergio Daniel Hernandez, Jordan Squair, Nicolò Macellari, Jimmy James Ravier, Carmina Andrea Galvez Solano, Grégory Didier Dumont

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Bayesian optimization of peripheral intraneural stimulation protocols to evoke distal limb movements

Sophie Marie Marthe Wurth, Marion Aimée Geneviève Badi-Dubois, Silvestro Micera, Grégoire Courtine, Simon Borgognon

Objective. Motor neuroprostheses require the identification of stimulation protocols that effectively produce desired movements. Manual search for these protocols can be very time-consuming and often leads to suboptimal solutions, as several stimulation pa ...

IOP Publishing Ltd2021

Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Nathan Antoine Greiner, Simon Borgognon, Nicholas David James, Henri Charles Alexandre Lorach

Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, located in the cervical spinal cord, suggesting t ...

Nature Research2021

Intrafascicular peripheral nerve stimulation produces fine functional hand movements in primates

Sophie Marie Marthe Wurth, Marion Aimée Geneviève Badi-Dubois, Silvestro Micera, Grégoire Courtine, Evgenia Vladimirova Roussinova, Simon Borgognon

Restoring dexterous hand control is critical for people with paralysis. Approaches based on surface or intramuscular stimulation provide limited finger control, generate insufficient force to recover functional movements, and require numerous electrodes. H ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Soft, Implantable Bioelectronic Interfaces for Translational Research

Sébastien Jiguet, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Evgenia Vladimirova Roussinova, Ivan Furfaro, Andreas Rowald, Beatrice Barra, Simon Borgognon, Jocelyne Bloch, Xiaoyang Kang, Ismael Seanez Gonzalez

The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐based innovation toward cli ...

Wiley2020

Cortical Projection From the Premotor or Primary Motor Cortex to the Subthalamic Nucleus in Intact and Parkinsonian Adult Macaque Monkeys: A Pilot Tracing Study

Simon Pierre Jean Badoud, Simon Borgognon, Jocelyne Bloch

Besides the main cortical inputs to the basal ganglia, via the corticostriatal projection, there is another input via the corticosubthalamic projection (CSTP), terminating in the subthalamic nucleus (STN). The present study investigated and compared the CS ...

FRONTIERS MEDIA SA2020