Publications by Jocelyne Bloch

Online prediction of optimal deep brain stimulation contacts from local field potentials in Parkinson’s disease

Selecting optimal contacts for chronic deep-brain stimulation (DBS) requires a monopolar review, involving time-consuming manual testing by trained personnel, often causing patient discomfort. Neural biomarkers, such as local field potentials (LFP), could ...

2025

A clinical road map for single-cell omics

Grégoire Courtine, Jocelyne Bloch

In a matter of years, single-cell omics has matured from a pioneering technique employed by just a handful of specialized laboratories to become a ubiquitous feature of biological research and a key driver of scientific discovery. The widespread adoption a ...

2025

Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept

Auke Ijspeert, Léonie Asboth, Salif Axel Komi, Grégoire Courtine, Miroslav Caban, Nicolas Hankov, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Jocelyne Bloch, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Cathal John Harte

Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. ...

AMER ASSOC ADVANCEMENT SCIENCE2025

Regional specialization of movement encoding across the primate sensorimotor cortex

Tomislav Milekovic, Grégoire Courtine, Simon Borgognon, Jocelyne Bloch, Ismael Seanez Gonzalez, Nicolò Macellari

The process by which the cerebral cortex generates movements to achieve different tasks remains poorly understood. Here, we leveraged the rich repertoire of well-controlled primate locomotor behaviors to study how task-specific movements are encoded across ...

Springer Science and Business Media LLC2025

High-resolution prosthetic hearing with a soft auditory brainstem implant in macaques

Florian Dylan Fallegger, Stéphanie Lacour, Florent-Valéry Coen, Emilie Cornelia Maria Revol, Ivan Furfaro, Laurine Kolly, Jocelyne Bloch, Alix Esther Anne Trouillet

Individuals with compromised cochlear nerves are ineligible for cochlear implants and instead rely on auditory brainstem implants (ABIs). Most users of ABIs experience sound awareness, which aids in lip reading, yet not speech intelligibility. Here we engi ...

2025

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

Bernard Schneider, Grégoire Courtine, Quentin Barraud, Michael V. Sofroniew, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Matthieu Pierre Gautier, Thomas Haynes Hutson, Michael Alexander Skinnider

Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same ...

Springer Science and Business Media LLC2024

System for control of spasticity

Salif Axel Komi, Grégoire Courtine, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Karen Minassian, Jocelyne Bloch

The present invention relates to a neuromodulation/neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: - at least one control unit (12) configured and arranged to provide stimulation data, and - at least o ...

2024

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Léonie Asboth, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Nicolas Hankov, Katia Galan, Robin Jonathan Demesmaeker, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Matthieu Pierre Gautier, Jimmy James Ravier, Thomas Haynes Hutson, Viviana Aureli

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

Lateral medullary vascular compression manifesting as paroxysmal hypertension

Jocelyne Bloch

Neurovascular compression of the rostral ventrolateral medulla (RVLM) has been described as a possible cause of refractory essential hypertension. We present the case of a patient affected by episodes of severe paroxysmal hypertension, some episodes associ ...

2024

Neuromodulation/neurostimulation system for controlling a respiratory function

Vincent Delattre, Léonie Asboth, Grégoire Courtine, Miroslav Caban, Nicolas Hankov, Robin Jonathan Demesmaeker, Jocelyne Bloch

The present invention relates to a neuromodulation/neurostimulation system for supporting and/or controlling a function of t he respiratory system of a patient, said function comprising a plurality of phases each involving one or more muscles. The system c ...

2024

System for micturition control in a mammal with bladder disfunction

Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Loïs Thomas Romain Mahe

The present invention relates to a neuromodulation/neurostimulation system (10) for stimulating at least one neuronal circuitry responsible for micturition control in a mammal with bladder disfunction, especially for bladder relaxation and/or for bladder v ...

2024

Neuromodulation/neurostimulation system for restoring a motor function and facilitating neurological recovery

Grégoire Courtine, Jocelyne Bloch, Henri Charles Alexandre Lorach

The present invention relates to a neuromodulation/neurostimulation system (100) for restoring a motor function of the upper and/or lower limbs and facilitating neurological recovery in a patient (P) with spinal cord injury (SCI) and/or other neurological ...

2024

A spinal neuroprosthesis against locomotor deficits in Parkinson's disease

Grégoire Courtine, Jocelyne Bloch

Edp Sciences S A2024

Walking naturally after spinal cord injury using a brain-spine interface

Léonie Asboth, Salif Axel Komi, Grégoire Courtine, Robin Jonathan Demesmaeker, Félix Antoine Martel, Laure Coquoz, Jocelyne Bloch, Anne Marie Lucienne Watrin, Sergio Daniel Hernandez, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Molywan Vat, Carmina Andrea Galvez Solano, Cathal John Harte, Valeria Spagnolo, Grégory Didier Dumont, Thibault Jean Etienne Collin, Icare Sakr, Lucas Struber

A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...

NATURE PORTFOLIO2023

A digital bridge between brain and spinal cord restores walking after paralysis

Grégoire Courtine, Jocelyne Bloch

Spinal-cord injury interrupts communication between the brain and spinal cord, leading to paralysis. An implant that decodes the brain signals that control movements and drives electrical stimulation of the spinal cord re-establishes this communication, en ...

NATURE PORTFOLIO2023

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Bernard Schneider, Grégoire Courtine, Quentin Barraud, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Katia Galan, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Marco Milano, Jordan Squair, Matthieu Pierre Gautier, Anna Lasne, Thomas Haynes Hutson, Steven Lee Ceto, Michael Alexander Skinnider

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

American Association for the Advancement of Science2023

Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?

Grégoire Courtine, Jocelyne Bloch, Friedhelm Christoph Hummel, Shiqi Sun, Estelle Emeline Raffin, Mahmut Yüksel

Stroke as the leading cause of adult long-term disability and has a significant impact on patients, society and socio-economics. Non-invasive brain stimulation (NIBS) approaches such as transcranial magnetic stimulation (TMS) or transcranial electrical sti ...

Ieee-Inst Electrical Electronics Engineers Inc2023

Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders

Tomislav Milekovic, Léonie Asboth, Grégoire Courtine, Eduardo Martin Moraud, Robin Jonathan Demesmaeker, Newton Cho, Jocelyne Bloch, Jordan Squair

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

2023

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Tomislav Milekovic, Léonie Asboth, Camille Georgette Marie Le Goff-Mignardot, Giuseppe Schiavone, Elvira Pirondini, Stéphanie Lacour, Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, David Allenson Borton, Jean François Pierre Laurens, Jean-Baptiste Mignardot, Flavio Raschella, Robin Jonathan Demesmaeker, Simon Borgognon, Jocelyne Bloch, Shiqi Sun, Sergio Daniel Hernandez, Jordan Squair, Nicolò Macellari, Jimmy James Ravier, Carmina Andrea Galvez Solano, Grégory Didier Dumont

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Targeted dorsal root entry zone stimulation alleviates pain due to meralgia paresthetica

Léonie Asboth, Grégoire Courtine, Nicolas Hankov, Robin Jonathan Demesmaeker, Jocelyne Bloch, Jimmy James Ravier, Molywan Vat, Viviana Aureli

Objective. Meralgia paresthetica (MP) is a mononeuropathy of the exclusively sensory lateral femoral cutaneous nerve (LFCN) that is difficult to treat with conservative treatments. Afferents from the LFCN enter the spinal cord through the dorsal root entry ...

IOP Publishing Ltd2022