Publications by Claudia Kathe | EPFL Graph Search

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

Bernard Schneider, Grégoire Courtine, Quentin Barraud, Michael V. Sofroniew, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Matthieu Pierre Gautier, Thomas Haynes Hutson, Michael Alexander Skinnider

Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same ...

Springer Science and Business Media LLC2024

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Léonie Asboth, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Nicolas Hankov, Katia Galan, Robin Jonathan Demesmaeker, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Matthieu Pierre Gautier, Jimmy James Ravier, Thomas Haynes Hutson, Viviana Aureli

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

Magnesium Test: Universal and Ultra-Sensitive Method for Measuring Reliability of Thin-Film-Encapsulated Bioelectronic Implants in Physiological Environment

Yves Leterrier, Stéphanie Lacour, Grégoire Courtine, Lei Wang, Ivan Furfaro, Claudia Kathe, Kangling Wu, Massimo Mariello

Next-generation bioelectronic implants require miniaturization, durability, and long-term functionality. Thin film encapsulations, prepared with inorganic or hybrid organic/inorganic designs, are essential for ensuring protection, low water permeation, ada ...

Wiley-V C H Verlag Gmbh2024

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Bernard Schneider, Grégoire Courtine, Quentin Barraud, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Katia Galan, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Marco Milano, Jordan Squair, Matthieu Pierre Gautier, Anna Lasne, Thomas Haynes Hutson, Steven Lee Ceto, Michael Alexander Skinnider

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

American Association for the Advancement of Science2023

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Léonie Asboth, Jérôme Gandar, Frédéric Pierre Gérald Michoud, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Noaf Salah Ali Alwahab, Ivan Furfaro, Ileana Ozana Jelescu, Andreas Rowald, Claudia Kathe, Valentina Marie Paggi, Jimmy James Ravier, Kyungjin Kim, Thomas Haynes Hutson

Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, ...

NATURE PORTFOLIO2022

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

Grégoire Courtine, Yi Ding, Claudia Kathe, Jordan Squair

After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these cells requires a clearer understanding of their injury responses and capacity for repair. Here, we use single nucleus RNA ...

Nature Portfolio2022

The neurons that restore walking after paralysis

Léonie Asboth, Salif Axel Komi, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Laetitia Danielle Philippine Baud, Katia Galan, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Matthieu Pierre Gautier, Kyungjin Kim, Thomas Haynes Hutson, Steven Lee Ceto

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Natural and targeted circuit reorganization after spinal cord injury

Grégoire Courtine, Quentin Barraud, Mark Andrew Anderson, Jocelyne Bloch, Claudia Kathe, Jordan Squair, Matthieu Pierre Gautier, Thomas Haynes Hutson

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. ...

NATURE PORTFOLIO2022

Confronting false discoveries in single-cell differential expression

Grégoire Courtine, Quentin Barraud, Mark Andrew Anderson, Claudia Kathe, Nicholas David James, Jordan Squair, Matthieu Pierre Gautier, Gioele La Manno, Thomas Haynes Hutson, Rémi Bernard René Hudelle, Michael Alexander Skinnider

Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries. ...

Nature Portfolio2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Jérôme Gandar, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Salif Axel Komi, Stéphanie Lacour, Arnaud Bichat, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Eduardo Martin Moraud, Marco Capogrosso, Mark Andrew Anderson, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Ileana Ozana Jelescu, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Laura Ann McCracken, Matthieu Pierre Gautier, Loïs Thomas Romain Mahe, Jimmy James Ravier

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

A Whole-Body Musculoskeletal Model of the Mouse

Auke Ijspeert, Jonathan Patrick Arreguit O'Neill, Grégoire Courtine, Dimitri Bruno Marie Rodarie, Claudia Kathe

Neural control of movement cannot be fully understood without careful consideration of interactions between the neural and biomechanical components. Recent advancements in mouse molecular genetics allow for the identification and manipulation of constituen ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2021

Cell type prioritization in single-cell data

Grégoire Courtine, Quentin Barraud, Mark Andrew Anderson, Claudia Kathe, Marco Milano, Jordan Squair, Matthieu Pierre Gautier, Gioele La Manno, Thomas Haynes Hutson, Michael Alexander Skinnider

The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis. ...

NATURE PUBLISHING GROUP2021

Transcriptional Dynamics Of Neurorehabilitation In Spinal Cord Injury At Single-Nucleus Resolution

Grégoire Courtine, Laetitia Danielle Philippine Baud, Claudia Kathe, Jordan Squair, Michael Alexander Skinnider

MARY ANN LIEBERT, INC2019

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Claudia Kathe, Thomas Haynes Hutson

After a spinal cord injury, axons fail to regenerate in the adult mammalian central nervous system, leading to permanent deficits in sensory and motor functions. Increasing neuronal activity after an injury using electrical stimulation or rehabilitation ca ...

AMER ASSOC ADVANCEMENT SCIENCE2019

RNA sequencing dataset describing transcriptional changes in cervical dorsal root ganglia after bilateral pyramidotomy and forelimb intramuscular gene therapy with an adeno-associated viral vector encoding human neurotrophin-3

Claudia Kathe

Unilateral or bilateral corticospinal tract injury in the medullary pyramids in adult rats causes anatomical and physiological changes in proprioceptive neurons projecting to the cervical spinal cord accompanied by hyperreflexia and abnormal behavioural mo ...

ELSEVIER SCIENCE BV2018