Publications by Erick Jorge Canales Rodriguez

Impact of Bipolar Disorder Increased White Matter Hyperintensities on White Matter Connectivity

Background: Individuals with bipolar disorder have been reported to have increased white matter hyperintensities (WMH) in fluid-attenuated inversion recovery (FLAIR) magnetic resonance scans. However, it is unknown whether this WMH increase has any impact ...

WILEY2025

Sulcal Pits as Potential Markers of Early Sex-related Human Brain Differences in Healthy Adults

Erick Jorge Canales Rodriguez

BMC2025

Brain microstructure alterations in subjective cognitive decline: a multi-component T2 relaxometry study

Erick Jorge Canales Rodriguez

Previous research has revealed patterns of brain atrophy in subjective cognitive decline, a potential preclinical stage of Alzheimer's disease. However, the involvement of myelin content and microstructural alterations in subjective cognitive decline has n ...

OXFORD UNIV PRESS2025

A diffusion MRI model for random walks confined on cylindrical surfaces: towards non-invasive quantification of myelin sheath radius

Jean-Philippe Thiran, Elda Fischi Gomez, Erick Jorge Canales Rodriguez

Introduction Quantifying the myelin sheath radius of myelinated axons in vivo is important for understanding, diagnosing, and monitoring various neurological disorders. Despite advancements in diffusion MRI (dMRI) microstructure techniques, there are curre ...

FRONTIERS MEDIA SA2025

Pore size estimation in axon-mimicking microfibers with diffusion-relaxation MRI

Jean-Philippe Thiran, Muhamed Barakovic, Erick Jorge Canales Rodriguez, Marco Pizzolato, Tim Bjørn Dyrby

Purpose: This study aims to evaluate two distinct approaches for fiber radius estimation using diffusion-relaxation MRI data acquired in biomimetic microfiber phantoms that mimic hollow axons. The methods considered are the spherical mean power-law approac ...

Wiley2024

NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia

Erick Jorge Canales Rodriguez

The expression of Neuritin-1 (NRN1), a neurotrophic factor crucial for neurodevelopment and synaptic plasticity, is enhanced by the Brain Derived Neurotrophic Factor (BDNF). Although the receptor of NRN1 remains unclear, it is suggested that NRN1's activat ...

Heidelberg2024

Spatial Prior Informed Constrained Spherical Deconvolution in Super Resolution Variation

Jean-Philippe Thiran, Gabriel Girard, Erick Jorge Canales Rodriguez, Juan Luis Villarreal Haro

Constrained Spherical Deconvolution (CSD) is a state-of-the-art technique for unraveling complex fiber configurations of white matter from diffusion MRI data. Despite its ability to identify multiple fiber orientations, it faces difficulties in resolving f ...

Springer Nature2024

Comparing Steam and PGSE Diffusion MRI Signal of RAT Lymph Nodes Using In-Silico Simulations

Jean-Philippe Thiran, Elda Fischi Gomez, Gabriel Girard, Erick Jorge Canales Rodriguez, Rémy Marc M Gardier, Juan Luis Villarreal Haro

Diffusion magnetic resonance imaging (dMRI) has demonstrated great capabilities to quantify tissue microstructure using biophysical diffusion models. Over the years, various gradient sequences have been proposed to provide sensitivity and specificity to va ...

IEEE Computer Society2024

Processing speed mediates the relationship between DDR1 and psychosocial functioning in euthymic patients with bipolar disorder presenting psychotic symptoms

Erick Jorge Canales Rodriguez

The DDR1 locus is associated with the diagnosis of schizophrenia and with processing speed in patients with schizophrenia and first-episode psychosis. Here, we investigated whether DDR1 variants are associated with bipolar disorder (BD) features. First, we ...

2024

In-Silico Trained AI for Enhanced T2Spectrum Imaging and Myelin Water Fraction Mapping in Preclinical 7T MRI

Jean-Philippe Thiran, Erick Jorge Canales Rodriguez, Thomas Yu

This study introduces a Machine Learning (ML) approach for estimating the T2 spectrum and myelin water fraction (MWF) using multi-echo T2 (MET2) data from preclinical 7T Magnetic Resonance Imaging (MRI) scanners. ML methods have shown promise in MWF estima ...

IEEE Computer Society2024

Tractography passes the test: Results from the diffusion-simulated connectivity (disco) challenge

Jean-Philippe Thiran, Alessandro Daducci, Ying-Chia Lin, Sara Sedlar, Caio Seguin, Gabriel Girard, Erick Jorge Canales Rodriguez, Alonso Ramirez Manzanares, Marco Pizzolato, Juan Luis Villarreal Haro, Kenji Marshall, Yang Ji

Estimating structural connectivity from diffusion-weighted magnetic resonance imaging is a challenging task, partly due to the presence of false-positive connections and the misestimation of connection weights. Building on previous efforts, the MICCAI-CDMR ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2023

Human-specific evolutionary markers linked to foetal neurodevelopment modulate brain surface area in schizophrenia

Erick Jorge Canales Rodriguez

Schizophrenia may represent a trade-off in the evolution of human-specific ontogenetic mechanisms that guide neurodevelopment. Human Accelerated Regions (HARs) are evolutionary markers functioning as neurodevelopmental transcription enhancers that have bee ...

2023

Improved estimation of the risk of manic relapse by combining clinical and brain scan data

Erick Jorge Canales Rodriguez

Introduction: Estimating the risk of manic relapse could help the psychiatrist individually adjust the treatment to the risk. Some authors have attempted to estimate this risk from baseline clinical data. Still, no studies have assessed whether the estimat ...

2023

Cellular EXchange Imaging (CEXI): Evaluation of a diffusion model including water exchange in cells using numerical phantoms of permeable spheres

Jean-Philippe Thiran, Ileana Ozana Jelescu, Gabriel Girard, Jonathan Rafael Patino Lopez, Erick Jorge Canales Rodriguez, Rémy Marc M Gardier, Juan Luis Villarreal Haro

Purpose Biophysical models of diffusion MRI have been developed to characterize microstructure in various tissues, but existing models are not suitable for tissue composed of permeable spherical cells. In this study we introduce Cellular Exchange Imaging ( ...

Wiley2023

Concurrent Validity and Reliability of Suicide Risk Assessment Instruments: A Meta-Analysis of 20 Instruments Across 27 International Cohorts

Erick Jorge Canales Rodriguez

Objective: A major limitation of current suicide research is the lack of power to identify robust correlates of suicidal thoughts or behavior. Variation in suicide risk assessment instruments used across cohorts may represent a limitation to pooling data i ...

2023

Estimating axon radius using diffusion-relaxation MRI: calibrating a surface-based relaxation model with histology

Jean-Philippe Thiran, Muhamed Barakovic, Erick Jorge Canales Rodriguez

Axon radius is a potential biomarker for brain diseases and a crucial tissue microstructure parameter that determines the speed of action potentials. Diffusion MRI (dMRI) allows non-invasive estimation of axon radius, but accurately estimating the radius o ...

FRONTIERS MEDIA SA2023

Axial and radial axonal diffusivities and radii from single encoding strongly diffusion-weighted MRI

Erick Jorge Canales Rodriguez, Marco Pizzolato, Tim Bjørn Dyrby

We enable the estimation of the per-axon axial diffusivity from single encoding, strongly diffusion-weighted, pulsed gradient spin echo data. Additionally, we improve the estimation of the per-axon radial diffusivity compared to estimates based on spherica ...

ELSEVIER2023

Widespread intra-axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion MRI: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment

Erick Jorge Canales Rodriguez

Despite diffusion tensor imaging (DTI) evidence for widespread fractional anisotropy (FA) reductions in the brain white matter of patients with bipolar disorder, questions remain regarding the specificity and sensitivity of FA abnormalities as opposed to o ...

Wiley2023

Through-Plane Super-Resolution With Autoencoders in Diffusion Magnetic Resonance Imaging of the Developing Human Brain

Meritxell Bach Cuadra, Hamza Kebiri, Gabriel Girard, Erick Jorge Canales Rodriguez

Fetal brain diffusion magnetic resonance images (MRI) are often acquired with a lower through-plane than in-plane resolution. This anisotropy is often overcome by classical upsampling methods such as linear or cubic interpolation. In this work, we employ a ...

FRONTIERS MEDIA SA2022

Microstructure estimation from diffusion-MRI: Compartmentalized models in permeable cellular tissue

Jean-Philippe Thiran, Gabriel Girard, Jonathan Rafael Patino Lopez, Erick Jorge Canales Rodriguez, Rémy Marc M Gardier, Juan Luis Villarreal Haro

Diffusion-weighted magnetic resonance imaging (DW-MRI) is used to characterize brain tissue microstructure employing tissue-specific biophysical models. A current limitation, however, is that most of the proposed models are based on the assumption of negli ...

2022