Marilena Wischnewski

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Related publications (4)

Exploring the mechanisms governing nuclear cGAS localization and activity

Marilena Wischnewski

Recognition of pathogen-derived molecules through germline-encoded receptors is a fundamental principle of innate immunity. Pattern recognition receptors detect specific intracellular danger signals to trigger potent immune responses. The DNA sensor cyclic ...

EPFL2022

Interplay of cGAS with chromatin

Andrea Ablasser, Marilena Wischnewski

Recognition of DNA is an evolutionarily highly conserved mechanism of immunity. In mammals, the cGAS-STING pathway plays a central role in coupling DNA sensing to the execution of innate immune mechanisms, both in contexts of infection as well as in noninf ...

ELSEVIER SCIENCE LONDON2021

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Beat Fierz, Andrea Ablasser, Mahmut Selman Sakar, Murat Kaynak, Baptiste Claude André Guey, Alexiane Clara Decout, Marilena Wischnewski, Kristina Makasheva

The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS). How cells regulate the activity of cGAS toward self-DNA and guard a ...

American Association for the Advancement of Science2020

Structure of the mitochondrial import gate reveals distinct preprotein paths

Thomas Becker, Jian Qiu, Marilena Wischnewski

The translocase of the outer mitochondrial membrane (TOM) is the main entry gate for proteins(1-4). Here we use cryo-electron microscopy to report the structure of the yeast TOM core complex(5-9) at 3.8-angstrom resolution. The structure reveals the high-r ...

2019

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