Publications by Wen Gao | EPFL Graph Search

A lysosomal surveillance response to stress extends healthspan

Johan Auwerx, Yang Li, Wen Gao, Xiaoxu Li, Amélia Lalou, Tanes Imamura de Lima, Qi Wang, Jia Liu

Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal ...

Springer Science and Business Media LLC2025

Systems genetics of metabolic health in the BXD mouse genetic reference population

Johan Auwerx, Maroun Bou Sleiman, Wen Gao, Jean-David Horacio Morel, Xiaoxu Li, Alessia De Masi, Amélia Lalou, Jia Liu

Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate genetic var ...

2024

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Elena Katsyuba, Johan Auwerx, Laurent Mouchiroud, Maroun Bou Sleiman, Yang Li, Gaby El Alam, Wen Gao, Jean-David Horacio Morel, Xiaoxu Li, Amélia Lalou

Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determinants in 85 C. e ...

2024

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

Johan Auwerx, Adrienne Joëlle Laurence Mottis, Yang Li, Wen Gao, Xiaoxu Li, Qi Wang

Lysosomes are central platforms for not only the degradation of macromolecules but also the integration of multiple signaling pathways. However, whether and how lysosomes mediate the mitochondrial stress response (MSR) remain largely unknown. Here, we demo ...

SPRINGERNATURE2023

Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans

Richardus Houtkooper, Wen Gao, Yuan Liu

Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced deleterious e ...

Nature Portfolio2022

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Johan Auwerx, Maroun Bou Sleiman, Giacomo Vincenzo Giorgio Von Alvensleben, Hao Li, Wen Gao

American Association for the Advancement of Science2022

Article Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

Johan Auwerx, Maroun Bou Sleiman, Yang Li, Gaby El Alam, Wen Gao, Amélia Lalou

The mitochondrial unfolded protein response (UPRmt) is a promising pharmacological target for aging and age-related diseases. However, the integrative analysis of the impact of UPRmt activation on different signaling layers in animals with different geneti ...

CELL PRESS2022

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Felix Naef, Kristina Schoonjans, Johan Auwerx, Hao Li, Yang Li, Wen Gao, Xiaoxu Li, Amélia Lalou, Nagammal Neelagandan, Jia Liu, Yuan Liu

To adapt mitochondrial function to the ever-changing intra- and extracellular environment, multiple mitochondrial stress response (MSR) pathways, including the mitochondrial unfolded protein response (UPRmt), have evolved. However, how the mitochondrial st ...

Rockefeller University Press2022

Identifying gene function and module connections by the integration of multispecies expression compendia

Stephan Morgenthaler, Elena Katsyuba, Kristina Schoonjans, Johan Auwerx, Fabrice David, Maroun Bou Sleiman, Daria Rukina, Andrea Komljenovic, Hao Li, Qingyao Huang, Yang Li, Changmyung Oh, Wen Gao

The functions of many eukaryotic genes are still poorly understood. Here, we developed and validated a new method, termed GeneBridge, which is based on two linked approaches to impute gene function and bridge genes with biological processes. First, Gene-Mo ...

Cold Spring Harbor Laboratory2019

Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin

Patrick Descombes, Carlos Canto Alvarez, Richardus Houtkooper, Sylviane Métairon, Joanna Ratajczak, Catherine Maclachlan, Wen Gao

Mitochondrial function can be influenced by mitochondrial shape and connectivity with other cellular organelles through fusion and fission processes. Disturbances in mitochondrial architecture and mitochondrial fusion related genes are observed in situatio ...

American Diabetes Association2016

Distributed Video Coding: Trends and Perspectives

Frédéric Dufaux, Wen Gao

This paper surveys recent trends and perspectives in distributed video coding. More specifically, issues such as coding efficiency, error resilience, multi-view coding, scalability, and applications beyond coding are overviewed. In addition, recent contrib ...

Hindawi Publishing Corporation2009