Publications by Simone Romeni | EPFL Graph Search

Multimodal closed-loop strategies for gait recovery after spinal cord injury and stroke via the integration of robotics and neuromodulation

Restoring the ability to walk is a priority for individuals with neurological disorders or neurotraumatic injuries, given its significant impact on independence and quality of life. Multimodal closed-loop strategies that integrate robotic assistance and ne ...

2025

Biophysical characterization of the recording of unmyelinated and myelinated fiber activity with peripheral interfaces

Silvestro Micera, Simone Romeni

Unmyelinated fibers account for a remarkable fraction of the peripheral nervous system and their activity is linked to many autonomic and somatic functions. While electrical recording of such activity from human-sized peripheral nerves holds significant po ...

2025

Epidural electrical stimulation facilitates motor recovery in spinal cord injury involving the conus medullaris: A case study

Silvestro Micera, Simone Romeni

Background: Emerging research increasingly supports that epidural spinal cord electrical stimulation (EES) combined with neurorehabilitation can improve motor recovery in spinal cord injury (SCI) subjects. Patients with lesions involving the medullary cone ...

2025

Characterization of Machine Learning-Based Surrogate Models of Neural Activation Under Electrical Stimulation

Silvestro Micera, Simone Romeni

Bioelectromagnetics published by Wiley Periodicals LLC on behalf of Bioelectromagnetics Society.Electrical stimulation of peripheral nerves via implanted electrodes has been shown to be a promising approach to restore sensation, movement, and autonomic fun ...

2025

High-frequency epidural electrical stimulation reduces spasticity and facilitates walking recovery in patients with spinal cord injury

Silvestro Micera, Simone Romeni

Spinal cord injury (SCI) causes severe motor and sensory deficits, and there are currently no approved treatments for recovery. Nearly 70% of patients with SCI experience pathological muscle cocontraction and spasticity, accompanied by clinical signs such ...

AMER ASSOC ADVANCEMENT SCIENCE2025

Kinematic Similarity of Overground and Self-paced Omnidirectional Treadmill Walking in Healthy and Parkinsonian Subjects

Silvestro Micera, Simone Romeni

The use of self-paced omnidirectional treadmills equipped with body weight support and virtual reality environments in the clinical practice may allow the training of walking in safe and repeatable conditions across different pathologies. One premise for t ...

Springer Nature2025

Decoding electroencephalographic responses to visual stimuli compatible with electrical stimulation

Silvestro Micera, Laura Toni, Fiorenzo Artoni, Simone Romeni

Electrical stimulation of the visual nervous system could improve the quality of life of patients affected by acquired blindness by restoring some visual sensations, but requires careful optimization of stimulation parameters to produce useful perceptions. ...

Aip Publishing2024

A method and system for optimizing design, implantation, and stimulation protocols of electrodes stimulating the nervous system

Silvestro Micera, Simone Romeni

A method for optimizing at least one of a geometry, an implantation procedure, and/or stimulation protocol of one or more electrodes for an electrical stimulation of a target structure in a nervous system of a living being by a computer device, the method ...

2024

Biophysically accurate and machine learning-based surrogate models to optimize neuroprosthesis design and operation

Simone Romeni

Electrical stimulation of the nervous system has emerged as a promising assistive technology in case of many injuries and illnesses across various parts of the nervous system. In particular, the invasive neuromodulation of the peripheral nervous system see ...

EPFL2024

A computational model to design wide field-of-view optic nerve neuroprostheses

Silvestro Micera, Simone Romeni, Gabriele Marino

Retinal stimulation (RS) allows restoring vision in blind patients, but it covers only a narrow region of the visual field. Optic nerve stimulation (ONS) has the potential to produce visual perceptions spanning the whole visual field, but it produces very ...

CELL PRESS2024

Machine-learning predictor of nerve fiber firing rate allows the automatic optimization of electrical stimulation protocols

Silvestro Micera, Simone Romeni, Luca Pierantoni, Gabriele Marino

Computational models have been widely employed to study the electrical stimulation of the nervous system. Still, most applications either study fundamental mechanisms underlying stimulation, or address qualitative scientific questions. When quantitative qu ...

IEEE2023

Reconstruction of nerve functional topography using recruitment curves enables selective electrical stimulation

Silvestro Micera, Simone Romeni, Bianca Ziliotto

Multi-polar stimulation protocols have been used in the past to increase the selectivity of electrical stimulation of the nervous system. Nonetheless, the number of possible multipolar stimulation protocols is prohibitively large and cannot be explored dur ...

IEEE2023

Method for determining the functional topography of a peripheral nerve

Silvestro Micera, Simone Romeni

A method for determining the functional topography of a peripheral nerve ( 10 ) of a user comprising the steps of prearranging an electrode ( 100 ) comprising a number n of channels c i , with i = 1,2..., n, arranging the electrode (100) in such a way that ...

2023

Combining biophysical models and machine learning to optimize implant geometry and stimulation protocol for intraneural electrodes

Silvestro Micera, Simone Romeni, Elena Losanno, Luca Pierantoni

Objective. Peripheral nerve interfaces have the potential to restore sensory, motor, and visceral functions. In particular, intraneural interfaces allow targeting deep neural structures with high selectivity, even if their performance strongly depends upon ...

IOP Publishing Ltd2023

A method to establish functional vagus nerve topography from electro-neurographic spontaneous activity

Silvestro Micera, Simone Romeni

Bioelectronic medicine is an emerging approach to treat many types of diseases via electrical stimulation of the autonomic nervous system (ANS). Because the vagus nerve (VN) is one of the most important nerves controlling several ANS functions, stimulation ...

2022

Computational model of the dorsal horn circuitry for innocuous touch

Silvestro Micera, Simone Romeni

Providing a naturalistic tactile sensory feedback is currently one of the key challenges in neuroprosthetics. Modeling has played a fundamental role in the development of "biomimetic" stimulation protocols, determining optimal activation patterns to be eli ...

IEEE2021

Simultaneous decoding of cardiovascular and respiratory functional changes from pig intraneural vagus nerve signals

Silvestro Micera, Ivo Strauss, Simone Romeni

Objective. Bioelectronic medicine is opening new perspectives for the treatment of some major chronic diseases through the physical modulation of autonomic nervous system activity. Being the main peripheral route for electrical signals between central nerv ...

IOP PUBLISHING LTD2021

Morphological Neural Computation Restores Discrimination of Naturalistic Textures in Trans-radial Amputees

Fabrizio Vecchio, Silvestro Micera, Francesco Maria Petrini, Ivo Strauss, Giacomo Valle, Roberto Puddu, Simone Romeni

Humans rely on their sense of touch to interact with the environment. Thus, restoring lost tactile sensory capabilities in amputees would advance their quality of life. In particular, texture discrimination is an important component for the interaction wit ...

Nature Research2020

Tutorial: a computational framework for the design and optimization of peripheral neural interfaces

Silvestro Micera, Giacomo Valle, Simone Romeni

Peripheral neural interfaces have been successfully used in the recent past to restore sensory-motor functions in disabled subjects and for the neuromodulation of the autonomic nervous system. The optimization of these neural interfaces is crucial for ethi ...

NATURE RESEARCH2020