Publications by Wayne Yang Wen Wei

Controlled Sensing of User-Defined Aptamer-Based Targets Using Scanning Ionic Conductance Spectroscopy

Aleksandra Radenovic, Lely Feletti, Georg Fantner, Barney Frederick Drake, Marcos Penedo Garcia, Helena Miljkovic, Wayne Yang Wen Wei, Zahra Ayar Dulabi

Solid-state nanopores offer the possibility of detecting disease biomarkers in early diagnostic applications. Standard approaches harness fingerprinting, where protein targets are bound to DNA carriers and detected in free translocation with a solid-state ...

2025

Label-Free Imaging of DNA Interactions with 2D Materials

Aleksandra Radenovic, Suliana Manley, Jenny Sülzle, Nathan Cyprien Arsène Ronceray, Yuta Shimoda, Eveline Simone Mayner, Wayne Yang Wen Wei

Two-dimensional (2D) materials offer potential as substrates for biosensing devices, as their properties can be engineered to tune interactions between the surface and biomolecules. Yet, not many methods can measure these interactions in a liquid environme ...

2024

Label-Free Techniques for Probing Biomolecular Condensates

Aleksandra Radenovic, Khalid Ashraf Mohie Ibrahim, Helena Miljkovic, Wayne Yang Wen Wei, Akhil Sai Naidu

Biomolecular condensates play important roles in a wide array of fundamental biological processes, such as cellular compartmentalization, cellular regulation, and other biochemical reactions. Since their discovery and first observations, an extensive and e ...

Amer Chemical Soc2024

Defect engineering of 2D material for biosensing applications

Aleksandra Radenovic, Suliana Manley, Michal Daniel Macha, Jenny Sülzle, Nathan Cyprien Arsène Ronceray, Yuta Shimoda, Eveline Simone Mayner, Wayne Yang Wen Wei

CELL PRESS2023

Imaging of interactions of biomolecules with nanomaterials with interferometric scattering microscopy

Aleksandra Radenovic, Suliana Manley, Michal Daniel Macha, Jenny Sülzle, Nathan Cyprien Arsène Ronceray, Yuta Shimoda, Eveline Simone Mayner, Wayne Yang Wen Wei

CELL PRESS2023

Enhancing ion extraction with an inverse sheath in negative hydrogen ion sources for NBI heating

Guang-Yu Sun, Wayne Yang Wen Wei

Negative hydrogen ion (H-) sources employed in neutral beam injection (NBI) systems are subject to extraction efficiency issues due to the considerable volumetric losses of negative hydrogen ions. Here, we propose to improve the H- extraction by activating ...

IOP Publishing Ltd2023

Scaffolding protein functional sites using deep learning

Basile Isidore Martin Wicky, Jue Wang, Bruno Emanuel Ferreira De Sousa Correia, Karla Montserrat Castro Gilabert, Wayne Yang Wen Wei

The binding and catalytic functions of proteins are generally mediated by a small number of functional residues held in place by the overall protein structure. Here, we describe deep learning approaches for scaffolding such functional sites without needing ...

American Association for the Advancement of Science2022

FIB-milled plasmonic nanoapertures allow for long trapping times of individual proteins

Wayne Yang Wen Wei

We have developed a fabrication methodology for label-free optical trapping of individual nanobeads and proteins in inverted-bowtie-shaped plasmonic gold nanopores. Arrays of these nanoapertures can be reliably produced using focused ion beam (FIB) milling ...

CELL PRESS2021