Publications by Marianne Liebi

Lack of embryonic skeletal muscle in mice leads to abnormal mineral deposition and growth

Developing bones can be severely impaired by a range of disorders where muscular loading is abnormal. Recent work has indicated that the effects of absent skeletal muscle on bones are more severe early in development, with rudiment length and mineralizatio ...

Elsevier2025

Fast Small-angle X-ray Scattering Tensor Tomography: an Outlook Into Future Applications in Life Sciences

Marianne Liebi, Manuel Guizar Sicairos

Small Angle-X-ray Scattering Tensor Tomography (SAS-TT) is a relatively new but powerful technique for studying the multiscale architecture of hierarchical structures particularly relevant to life science applications. Currently, the technique is very dema ...

WILEY-V C H VERLAG GMBH2025

Texture tomography with high angular resolution utilizing sparsity

Marianne Liebi

We demonstrate an approach to the reconstruction of scanning probe X-ray diffraction tomography data with anisotropic polycrystalline samples. The method involves reconstructing a voxel map containing an orientation distribution function in each voxel of a ...

2025

Supramolecular modification of sustainable high-molar-mass polymers for improved processing and performance

Holger Frauenrath, Daniel Görl, Nicolas Candau, Yevhen Hryshunin, Oguzhan Oguz, Marianne Liebi

The plastic waste crisis is among humanity’s most urgent challenges. However, widespread adoption of sustainable plastics is hindered by their often inadequate processing characteristics and performance. Here, we introduce a bio-inspired strategy for the m ...

Nature Research2025

Biomimetic Mineralization of Keratin Scaffolds for Enamel Regeneration

Marianne Liebi

Biomimetic protein-based platforms, with their hierarchical networks and optimal mechanical properties, show promising potential for hard tissue regeneration, including dental enamel. However, achieving aligned enamel-like apatite nanocrystals from organic ...

2025

Reconstructing Three‐Dimensional Optical Anisotropy with Tomographic Müller‐Polarimetric Microscopy

Marianne Liebi

Most visible light imaging methods using polarization to obtain ultrastructure information are limited to 2D analysis or require demanding phase measurements to be extended to 3D. A novel 3D polarized light imaging technique based on Müller‐matrix formulat ...

Wiley2025

Resolving the Sodiation Process in Hard Carbon Anodes with Nanostructure Specific X‐Ray Imaging

Marianne Liebi

Hard carbons show significant promise as anode materials for sodium‐ion batteries. However, monitoring the sodiation process in the hard carbon electrode during cycling and understanding the sodiation mechanism remain challenging. This article reports on o ...

Wiley2025

ForMAX - a beamline for multiscale and multimodal structural characterization of hierarchical materials

Vitor Silva, Zhongwen Yao, Yi Zhang, Marianne Liebi, Yiming Li

The ForMAX beamline at the MAX IV Laboratory provides multiscale and multimodal structural characterization of hierarchical materials in the nanometre to millimetre range by combining small- and wide-angle X-ray scattering with full-field microtomography. ...

Int Union Crystallography2024

Unveiling breast cancer metastasis through an advanced X-ray imaging approach

Marianne Liebi

Breast cancer is a significant global health burden, causing a substantial number of deaths. Systemic metastatic tumour cell dissemination is a major cause of poor outcomes. Understanding the mechanisms underlying metastasis is crucial for effective interv ...

Nature Portfolio2024

X-ray tensor tomography for small-grained polycrystals with strong texture

Marianne Liebi

Small-angle X-ray tensor tomography and the related wide-angle X-ray tensor tomography are X-ray imaging techniques that tomographically reconstruct the anisotropic scattering density of extended samples. In previous studies, these methods have been used t ...

INT UNION CRYSTALLOGRAPHY2024

Crossing length scales: X-ray approaches to studying the structure of biological materials

Marianne Liebi

Biological materials have outstanding properties. With ease, challenging mechanical, optical or electrical properties are realised from comparatively 'humble' building blocks. The key strategy to realise these properties is through extensive hierarchical s ...

INT UNION CRYSTALLOGRAPHY2024

Process-Induced Structures of Injection-Molded High-Density Polyethylene-Combining X-ray Scattering and Finite Element Modeling

Marianne Liebi, Manuel Guizar Sicairos

The success of plastics heavily relies on fast melt processing methods used for large-scale industrial manufacturing, including injection molding. The hierarchical structure of the solid polymer depends on material selection combined with processing condit ...

Amer Chemical Soc2024

Phase-separated polymer blends for controlled drug delivery by tuning morphology

Marianne Liebi

Controlling drug release rate and providing physical and chemical stability to the active pharmaceutical ingredient are key properties of oral solid dosage forms. Here, we demonstrate a formulation strategy using phase-separated polymer blends where the mo ...

SPRINGERNATURE2024

Investigating the missing-wedge problem in smallangle X-ray scattering tensor tomography across real and reciprocal space

Marianne Liebi

Small-angle-scattering tensor tomography is a technique for studying anisotropic nanostructures of millimetre-sized samples in a volume-resolved manner. It requires the acquisition of data through repeated tomographic rotations about an axis which is subje ...

INT UNION CRYSTALLOGRAPHY2024

Physical exercise impacts bone remodeling around bio-resorbable magnesium implants

Marianne Liebi

Physical exercise has been shown to induce positive reactions in bone healing but next to nothing is known about how it affects the nanostructure, in particular around implants. In this study, we established this link by using small-angle X-ray scattering ...

2024

Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation

Antonia Neels, Tiberiu Totu, Marianne Liebi

Intravenous (IV) iron-carbohydrate complexes are widely used nanoparticles (NPs) to treat iron deficiency anaemia, often associated with medical conditions such as chronic kidney disease, heart failure and various inflammatory conditions. Even though a ple ...

Elsevier2024

Painting Taylor vortices with cellulose nanocrystals: Suspension flow supercritical spectral dynamics

Marianne Liebi

We study the flow stability and spatiotemporal spectral dynamics of cellulose nanocrystal (CNC) suspensions in a custom Taylor-Couette flow cell using the intrinsic shear induced birefringence and liquid crystalline properties of CNC suspensions for flow v ...

Aip Publishing2024

Propagation of Orientation Across Lengthscales in Sheared Self-Assembling Hierarchical Suspensions via Rheo-PLI-SAXS

Marianne Liebi

Simultaneous rheological, polarized light imaging, and small-angle X-ray scattering experiments (Rheo-PLI-SAXS) are developed, thereby providing unprecedented level of insight into the multiscale orientation of hierarchical systems in simple shear. Notably ...

WILEY2024

Scanning Small-Angle X-ray Scattering of Injection-Molded Polymers: Anisotropic Structure and Mechanical Properties of Low-Density Polyethylene

Marianne Liebi, Manuel Guizar Sicairos

Injection molding is known to create a layered anisotropicmorphologyacross the sample thickness due to varying shear and cooling ratesduring the manufacturing process. In this study, scanning small-angleX-ray scattering was used to visualize and quantify t ...

AMER CHEMICAL SOC2023

Micro- and nanostructure specific X-ray tomography reveals less matrix formation and altered collagen organization following re duce d loading during Achilles tendon healing

Marianne Liebi

Recovery of the collagen structure following Achilles tendon rupture is poor, resulting in a high risk for re-ruptures. The loading environment during healing affects the mechanical properties of the tendon, but the relation between loading regime and heal ...

Elsevier Sci Ltd2023