Publication

Gold finger formation studied by high-resolution mass spectrometry and in silico methods

Yury Tsybin, Angela Casini, Unige Anna Laskay
2015
Journal Articles

Abstract

High-resolution mass spectrometry and quantum mechanics/molecular mechanics studies were employed for characterizing the formation of two gold finger (GF) domains from the reaction of zinc fingers (ZF) with gold complexes. The influence of both the gold oxidation state and the ZF coordination sphere in GF formation provided useful insights into the possible design of new gold complexes targeting specific ZF motifs.

Official source

https://infoscience.epfl.ch/entities/publication/24443d04-8457-4cfd-bf61-54070a987f76

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Yury Tsybin, Angela Casini, Unige Anna Laskay
2015
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/24443d04-8457-4cfd-bf61-54070a987f76

About this result

Related concepts (16)

Mass spectrometry

Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a mass spectrum, a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures. A mass spectrum is a type of plot of the ion signal as a function of the mass-to-charge ratio.

Resolution (mass spectrometry)

In mass spectrometry, resolution is a measure of the ability to distinguish two peaks of slightly different mass-to-charge ratios ΔM, in a mass spectrum. There are two different definitions of resolution and resolving power in mass spectrometry. The IUPAC definition for resolution in mass spectrometry is Where a larger resolution indicates a better separation of peaks. This definition is used in a number of mass spectrometry texts. This use is also implied by the term "high-resolution mass spectrometry.

Liquid chromatography–mass spectrometry

Liquid chromatography–mass spectrometry (LC–MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography - MS systems are popular in chemical analysis because the individual capabilities of each technique are enhanced synergistically. While liquid chromatography separates mixtures with multiple components, mass spectrometry provides spectral information that may help to identify (or confirm the suspected identity of) each separated component.

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