Publication

Bioluminescence imaging of small biomolecules

Aurélien Godinat, Riccardo Sinisi, Elena Goun, Grigory Karateev, Ghyslain Martial Alain Budin, Aleksandra Konovalova, Jens Tomas Frigell
2014
Patents

Abstract

The invention relates to a technique to detect small molecules using Bioluminescence imaging (BLI) to image and quantify non-invasively, in vitro and in vivo,intracellular metabolite fluxes and which can be applied to azido-modified compounds, such as azido-modified biomolecules.

Official source

https://infoscience.epfl.ch/entities/publication/2a0aad34-37ef-4598-81dc-bae435655a54

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Aurélien Godinat, Riccardo Sinisi, Elena Goun, Grigory Karateev, Ghyslain Martial Alain Budin, Aleksandra Konovalova, Jens Tomas Frigell
2014
Patents

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/2a0aad34-37ef-4598-81dc-bae435655a54

About this result

Related concepts (14)

Bioluminescence

Bioluminescence is the production and emission of light by living organisms. It is a form of chemiluminescence. Bioluminescence occurs widely in marine vertebrates and invertebrates, as well as in some fungi, microorganisms including some bioluminescent bacteria, and terrestrial arthropods such as fireflies. In some animals, the light is bacteriogenic, produced by symbiotic bacteria such as those from the genus Vibrio; in others, it is autogenic, produced by the animals themselves.

Bioluminescence imaging

Bioluminescence imaging (BLI) is a technology developed over the past decades (1990's and onward). that allows for the noninvasive study of ongoing biological processes Recently, bioluminescence tomography (BLT) has become possible and several systems have become commercially available. In 2011, PerkinElmer acquired one of the most popular lines of optical imaging systems with bioluminescence from Caliper Life Sciences. Bioluminescence is the process of light emission in living organisms.

Luciferin

Luciferin () is a generic term for the light-emitting compound found in organisms that generate bioluminescence. Luciferins typically undergo an enzyme-catalyzed reaction with molecular oxygen. The resulting transformation, which usually involves splitting off a molecular fragment, produces an excited state intermediate that emits light upon decaying to its ground state. The term may refer to molecules that are substrates for both luciferases and photoproteins.

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