DNA repairDNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes.
Cluster analysisCluster analysis or clustering is the task of grouping a set of objects in such a way that objects in the same group (called a cluster) are more similar (in some sense) to each other than to those in other groups (clusters). It is a main task of exploratory data analysis, and a common technique for statistical data analysis, used in many fields, including pattern recognition, , information retrieval, bioinformatics, data compression, computer graphics and machine learning.
Matrix multiplication algorithmBecause matrix multiplication is such a central operation in many numerical algorithms, much work has been invested in making matrix multiplication algorithms efficient. Applications of matrix multiplication in computational problems are found in many fields including scientific computing and pattern recognition and in seemingly unrelated problems such as counting the paths through a graph. Many different algorithms have been designed for multiplying matrices on different types of hardware, including parallel and distributed systems, where the computational work is spread over multiple processors (perhaps over a network).
High availabilityHigh availability (HA) is a characteristic of a system that aims to ensure an agreed level of operational performance, usually uptime, for a higher than normal period. Modernization has resulted in an increased reliance on these systems. For example, hospitals and data centers require high availability of their systems to perform routine daily activities. Availability refers to the ability of the user community to obtain a service or good, access the system, whether to submit new work, update or alter existing work, or collect the results of previous work.
High-availability clusterHigh-availability clusters (also known as HA clusters, fail-over clusters) are groups of computers that support server applications that can be reliably utilized with a minimum amount of down-time. They operate by using high availability software to harness redundant computers in groups or clusters that provide continued service when system components fail. Without clustering, if a server running a particular application crashes, the application will be unavailable until the crashed server is fixed.
Globular clusterA globular cluster is a spheroidal conglomeration of stars. Globular clusters are bound together by gravity, with a higher concentration of stars towards their centers. They can contain anywhere from tens of thousands to many millions of member stars. Their name is derived from Latin globulus (small sphere). Globular clusters are occasionally known simply as "globulars". Although one globular cluster, Omega Centauri, was observed in antiquity and long thought to be a star, recognition of the clusters' true nature came with the advent of telescopes in the 17th century.
Computational complexity of matrix multiplicationIn theoretical computer science, the computational complexity of matrix multiplication dictates how quickly the operation of matrix multiplication can be performed. Matrix multiplication algorithms are a central subroutine in theoretical and numerical algorithms for numerical linear algebra and optimization, so finding the right amount of time it should take is of major practical relevance. Directly applying the mathematical definition of matrix multiplication gives an algorithm that requires n3 field operations to multiply two n × n matrices over that field (Θ(n3) in big O notation).
Computer clusterA computer cluster is a set of computers that work together so that they can be viewed as a single system. Unlike grid computers, computer clusters have each node set to perform the same task, controlled and scheduled by software. The components of a cluster are usually connected to each other through fast local area networks, with each node (computer used as a server) running its own instance of an operating system. In most circumstances, all of the nodes use the same hardware and the same operating system, although in some setups (e.
Hierarchical clusteringIn data mining and statistics, hierarchical clustering (also called hierarchical cluster analysis or HCA) is a method of cluster analysis that seeks to build a hierarchy of clusters. Strategies for hierarchical clustering generally fall into two categories: Agglomerative: This is a "bottom-up" approach: Each observation starts in its own cluster, and pairs of clusters are merged as one moves up the hierarchy. Divisive: This is a "top-down" approach: All observations start in one cluster, and splits are performed recursively as one moves down the hierarchy.
Star clusterStar clusters are large groups of stars held together by self-gravitation. Two main types of star clusters can be distinguished: globular clusters are tight groups of ten thousand to millions of old stars which are gravitationally bound, while open clusters are more loosely clustered groups of stars, generally containing fewer than a few hundred members, and are often very young.
Nucleotide excision repairNucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions in DNA, it can correct only damaged bases that are removed by specific glycosylases.
Correlation clusteringClustering is the problem of partitioning data points into groups based on their similarity. Correlation clustering provides a method for clustering a set of objects into the optimum number of clusters without specifying that number in advance. Cluster analysis In machine learning, correlation clustering or cluster editing operates in a scenario where the relationships between the objects are known instead of the actual representations of the objects.
Open clusterAn open cluster is a type of star cluster made of tens to a few thousand stars that were formed from the same giant molecular cloud and have roughly the same age. More than 1,100 open clusters have been discovered within the Milky Way galaxy, and many more are thought to exist. They are loosely bound by mutual gravitational attraction and become disrupted by close encounters with other clusters and clouds of gas as they orbit the Galactic Center.
Distributed version controlIn software development, distributed version control (also known as distributed revision control) is a form of version control in which the complete codebase, including its full history, is mirrored on every developer's computer. Compared to centralized version control, this enables automatic management branching and merging, speeds up most operations (except pushing and pulling), improves the ability to work offline, and does not rely on a single location for backups.
Multiplication algorithmA multiplication algorithm is an algorithm (or method) to multiply two numbers. Depending on the size of the numbers, different algorithms are more efficient than others. Efficient multiplication algorithms have existed since the advent of the decimal system. If a positional numeral system is used, a natural way of multiplying numbers is taught in schools as long multiplication, sometimes called grade-school multiplication, sometimes called the Standard Algorithm: multiply the multiplicand by each digit of the multiplier and then add up all the properly shifted results.
Asymptotically optimal algorithmIn computer science, an algorithm is said to be asymptotically optimal if, roughly speaking, for large inputs it performs at worst a constant factor (independent of the input size) worse than the best possible algorithm. It is a term commonly encountered in computer science research as a result of widespread use of big-O notation. More formally, an algorithm is asymptotically optimal with respect to a particular resource if the problem has been proven to require Ω(f(n)) of that resource, and the algorithm has been proven to use only O(f(n)).
Galaxy clusterA galaxy cluster, or a cluster of galaxies, is a structure that consists of anywhere from hundreds to thousands of galaxies that are bound together by gravity, with typical masses ranging from 1014 to 1015 solar masses. They are the second-largest known gravitationally bound structures in the universe after galaxy filaments and were believed to be the largest known structures in the universe until the 1980s, when superclusters were discovered. One of the key features of clusters is the intracluster medium (ICM).
Application serverAn application server is a server that hosts applications or software that delivers a business application through a communication protocol. An application server framework is a service layer model. It includes software components available to a software developer through an application programming interface. An application server may have features such as clustering, fail-over, and load-balancing. The goal is for developers to focus on the business logic.
Base excision repairBase excision repair (BER) is a cellular mechanism, studied in the fields of biochemistry and genetics, that repairs damaged DNA throughout the cell cycle. It is responsible primarily for removing small, non-helix-distorting base lesions from the genome. The related nucleotide excision repair pathway repairs bulky helix-distorting lesions. BER is important for removing damaged bases that could otherwise cause mutations by mispairing or lead to breaks in DNA during replication.
Information theoryInformation theory is the mathematical study of the quantification, storage, and communication of information. The field was originally established by the works of Harry Nyquist and Ralph Hartley, in the 1920s, and Claude Shannon in the 1940s. The field, in applied mathematics, is at the intersection of probability theory, statistics, computer science, statistical mechanics, information engineering, and electrical engineering. A key measure in information theory is entropy.
