Hydropower is the world’s most important renewable electricity source. More than 40% of European hydroelectric energy is produced in Alpine countries. High-head storage hydropower plants (HPP) contribute significantly to peak energy production as well as electricity grid regulation. Future plant management is faced with several challenges concerning modified availability of water resources due to climate change as well as new economic constraints associated with legal, political and electricity market issues. HPP operation results in unsteady water release to the downstream river system. Hydropeaking is the primary factor of flow regime alteration, impacting the river ecosystem. Even when the biological response to hydropeaking is not fully understood, the recently adapted law on water protection prescribes its mitigation in Switzerland. In this research project, a novel integrative approach to model and assess the impact of the operation of a complex hydropower scheme on the downstream river system is developed. It contains (1) a precipitation-runoff model extended for long-term simulations of glacierized Alpine catchment areas, (2) an operation tool for high-head storage HPP, (3) flow regime generation with cost estimation of hydropeaking mitigation measures and (4) a habitat model of reference river morphologies for a target species. The upper Aare River (Hasliaare) in Switzerland is an Alpine stream, affected by hydropeaking from a complex hydropower scheme with several storage volumes and power houses. Since the 1930s, seasonal water transfer from summer to winter and the amplitude and frequency of daily peak discharge have been continuously increased. Furthermore, the dynamic braided river network with various mesohabitats gave way to a mainly monotonous channel. Although diversity of species and biomass of aquatic biota have drastically decreased, the potential of redevelopment remains. Investigations to improve the river morphology and the flow regime are under discussion. The upper Aare River catchment is therefore an appropriate case study for analysis of the interactions between climatic, hydrological, hydraulic, economic as well as ecological parameters. The simulation of runoff in Alpine catchment areas is essential for optimal hydropower exploitation under normal flow conditions, but also for the analysis of flood events. The semi-distributed conceptual modeling approach Routing System contains a reservoir-based precipitation-runoff transformation model (GSM-SOCONT), extended by dynamic glacier simulation tool. Spatial precipitation and temperature distributions are taken into account for simulating the relevant hydrological processes, such as glacier melt, snowpack constitution and melt, soil infiltration and runoff. The model development, calibration and validation are illustrated for the 2005 flood event, where the flood reduction capacity of the HPP is discussed, as well as future long-term runoff estimations. Climate change sce