Publication

Virology: Poxins Soothe the STING

Andrea Ablasser, Alexiane Clara Decout
2019
Journal Articles

Abstract

The mammalian cyclic dinucleotide 2', 3'-cGAMP is a potent inducer of innate immune responses produced upon detection of cytosolic DNA by cGAS. The mechanisms underlying the control of intracellular cGAMP levels remained unclear. In a new study, Eaglesham et al. identified poxins as 2', 3'-cGAMP-specific nucleases allowing immune evasion by viruses.

Official source

https://infoscience.epfl.ch/entities/publication/50c4a274-58dc-43fa-8979-ff6448073992

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Andrea Ablasser, Alexiane Clara Decout
2019
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/50c4a274-58dc-43fa-8979-ff6448073992

About this result

Related concepts (12)

Innate immune system

The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an alternate defense strategy and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms (see Beyond vertebrates).

Immune response

An immune response is a physiological reaction which occurs within an organism in the context of inflammation for the purpose of defending against exogenous factors. These include a wide variety of different toxins, viruses, intra- and extracellular bacteria, protozoa, helminths, and fungi which could cause serious problems to the health of the host organism if not cleared from the body. In addition, there are other forms of immune response.

Adaptive immune system

The adaptive immune system, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens.

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