Publication

Degradable Polymer Brushes Prepared via Surface-Initiated Controlled Radical Polymerization

Harm-Anton Klok, Nicolas Bertrand Schüwer, Carl Riachi
2009
Journal Articles

Abstract

Hydrolytically degradable polymer brushes would represent an interesting platform for the development of functional coatings for various biomaterials applications In this manuscript, the surface- initiated atom transfer radical copolymerization of 5.6-benzo-2-methylene1,3-dioxepane (BMDO) and poly(ethylene glycol) methacrylate (PEGMA) has been investigated to prepare degradable po;ymer brushes. The copolymerization of BMDO and PEGMA results in brushes that contain hydrolytically labile ester linkages in the polymer backbone. The thickness of these polymer brushes can be controlled via the polymerization time and the BMDO content by adjusting the monomer feed composition The degradation of the brushes was investigated by ellipsometry and atomic force microscopy (AFM) experiments While the brushes were relatively stable under neutral and mild-basic conditions (pH 9), degradation was significantly enhanced under acidic conditions Degradation was found to be accelerated at low pH values (pH 3-5) and with increasing BMDO content

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https://infoscience.epfl.ch/entities/publication/586e2eac-555a-4d6c-9b3e-2bd249939185

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Harm-Anton Klok, Nicolas Bertrand Schüwer, Carl Riachi
2009
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/586e2eac-555a-4d6c-9b3e-2bd249939185

About this result

Related concepts (21)

Polymer

A polymer (ˈpɒlᵻmər; Greek poly-, "many" + -mer, "part") is a substance or material consisting of very large molecules called macromolecules, composed of many repeating subunits. Due to their broad spectrum of properties, both synthetic and natural polymers play essential and ubiquitous roles in everyday life. Polymers range from familiar synthetic plastics such as polystyrene to natural biopolymers such as DNA and proteins that are fundamental to biological structure and function.

Radical polymerization

In polymer chemistry, free-radical polymerization (FRP) is a method of polymerization by which a polymer forms by the successive addition of free-radical building blocks (repeat units). Free radicals can be formed by a number of different mechanisms, usually involving separate initiator molecules. Following its generation, the initiating free radical adds (nonradical) monomer units, thereby growing the polymer chain. Free-radical polymerization is a key synthesis route for obtaining a wide variety of different polymers and materials composites.

Anionic addition polymerization

In polymer chemistry, anionic addition polymerization is a form of chain-growth polymerization or addition polymerization that involves the polymerization of monomers initiated with anions. The type of reaction has many manifestations, but traditionally vinyl monomers are used. Often anionic polymerization involves living polymerizations, which allows control of structure and composition. As early as 1936, Karl Ziegler proposed that anionic polymerization of styrene and butadiene by consecutive addition of monomer to an alkyl lithium initiator occurred without chain transfer or termination.

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