Publication

Bio-functionalization study of Memristive- Biosensors for Early Detection of Prostate Cancer

Giovanni De Micheli, Sandro Carrara, Ioulia Tzouvadaki
2015
Conference Papers

Abstract

Silicon nanowires are reported for their application in bio sensing area and their potential in the detection of various biomolecules. In the present work, freestanding two-terminal Schottky-barrier silicon nanowire arrays exhibiting memristive behavior are fabricated to obtain Memristive-Biosensors. Scanning electron microscopy reveal details on the morphology of the fabricated structures. The memristive devices are functionalized with anti-free-Prostate Specific Antigen (PSA) antibody by two strategies: a) direct passive adsorption on the device surface, and b) bio-affinity approach using Biotin-Streptavidin combination. The electrical behavior of the so-obtained Memristive-Biosensors is examined dealing with the two systems of bio-functionalization. The presence of biomolecules linked to the surface of the nanostructures is detected by a voltage gap appearing in the memristive electrical characteristics. The system shows the potential for applications in molecular diagnostics especially due to possibilities for detection in the femto molar ranges that allow early detection of the cancer disease.

Official source

https://infoscience.epfl.ch/entities/publication/6620a3bb-1d28-43d1-945b-a14d5de47153

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Giovanni De Micheli, Sandro Carrara, Ioulia Tzouvadaki
2015
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/6620a3bb-1d28-43d1-945b-a14d5de47153

About this result

Related concepts (16)

Prostate cancer

Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system just below the bladder. Early prostate cancer usually causes no symptoms. As the tumor grows, it can damage nearby organs causing erectile dysfunction, blood in the urine or semen, and trouble urinating. Some tumors eventually spread to other areas of the body, particularly the bones and lymph nodes. There, tumors cause severe bone pain, leg weakness or paralysis, and eventually death.

Memristor

A memristor (ˈmɛmrᵻstər; a portmanteau of memory resistor) is a non-linear two-terminal electrical component relating electric charge and magnetic flux linkage. It was described and named in 1971 by Leon Chua, completing a theoretical quartet of fundamental electrical components which comprises also the resistor, capacitor and inductor. Chua and Kang later generalized the concept to memristive systems. Such a system comprises a circuit, of multiple conventional components, which mimics key properties of the ideal memristor component and is also commonly referred to as a memristor.

Prostate-specific antigen

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus.

Related publications (31)

6-diazo-5-oxo-l-norleucine prodrugs

Xile Hu, Li Tang, Céline Jasmin Prange

The present invention relates to 6-diazo-5-oxo-L-norleucine prodrugs having reduced toxicity and increased tumor specificity and to their therapeutic use for treating cancer. ...

2024

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

Ali Ghasemi

Dendritic cells (DCs) are specialized myeloid cells with the ability to uptake, process, and present antigens to T lymphocytes. They also generate cytokine and chemokine gradients that regulate immune cell trafficking, activation, and function. Monocyte-de ...

EPFL2024

The conceptual foundations of innate immunity: Taking stock 30 years later

Bruno Lemaitre

While largely neglected over decades during which adaptive immunity captured most of the attention, innate immune mechanisms have now become central to our understanding of immunology. Innate immunity provides the first barrier to infection in vertebrates, ...

2024