Publication

Field confinement with aberration correction for solid immersion lens based fluorescence correlation spectroscopy

Theo Lasser, Ramachandra Rao, Rainer Leitgeb, Jelena Mitic
2007
Journal Articles

Abstract

The solid immersion lens (SIL) as a tool for increasing the field confinement as well as providing optimal performance by aberration compensation in a confocal fluorescence correlation spectroscopy (FCS) system is illustrated here. Using Zernike polynomials we show that aberration compensation and the resultant pre-shaping of the incident wavefront enables near diffraction-limited performance. This is explained based on vectorial computations for high apertures in the Debye approximation. The obtained axial resolution parameters are compared with the obtained diffusion times in a SIL-FCS experiment for measurements in solutions done at the single molecule level.

Official source

https://infoscience.epfl.ch/entities/publication/726506fe-463d-4fbc-8882-5db16a9ecc99

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Theo Lasser, Ramachandra Rao, Rainer Leitgeb, Jelena Mitic
2007
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/726506fe-463d-4fbc-8882-5db16a9ecc99

About this result

Related concepts (28)

Diffraction-limited system

In optics, any optical instrument or system a microscope, telescope, or camera has a principal limit to its resolution due to the physics of diffraction. An optical instrument is said to be diffraction-limited if it has reached this limit of resolution performance. Other factors may affect an optical system's performance, such as lens imperfections or aberrations, but these are caused by errors in the manufacture or calculation of a lens, whereas the diffraction limit is the maximum resolution possible for a theoretically perfect, or ideal, optical system.

Magnetic confinement fusion

Magnetic confinement fusion is an approach to generate thermonuclear fusion power that uses magnetic fields to confine fusion fuel in the form of a plasma. Magnetic confinement is one of two major branches of fusion energy research, along with inertial confinement fusion. The magnetic approach began in the 1940s and absorbed the majority of subsequent development. Fusion reactions combine light atomic nuclei such as hydrogen to form heavier ones such as helium, producing energy.

Optical aberration

In optics, aberration is a property of optical systems, such as lenses, that causes light to be spread out over some region of space rather than focused to a point. Aberrations cause the image formed by a lens to be blurred or distorted, with the nature of the distortion depending on the type of aberration. Aberration can be defined as a departure of the performance of an optical system from the predictions of paraxial optics.

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