Publication

Highly water soluble trithiolato-bridged dinuclear arene ruthenium complexes

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Noelia Claude Herrero
2014
Journal Articles

Abstract

Water soluble arene-functionalised trithiolato-bridged ruthenium complexes of general formula (eta(6)-C6H5OCH2CH2OH)(2)Ru-2(mu-SR)(3), where R = C6H5 (1), C6H4-p-OMe (2), C6H4-p-OMe (3), C6H4-p-Pr-i (4), C6H4-p-Bu-t (5), CH2C6H5 (6), CH2CH2C6H5 (7) and CH2C6H4-p-Bu-t (8), were prepared from the reaction of [(eta(6)-C6H5OCH2CH2OH)(2)Ru-2(mu-Cl)(2)Cl-2] with the corresponding thiol, RSH. Complexes [1] Cl-[8]Cl were isolated in good yields as their chloride salts and they were fully characterised using spectroscopic and analytical techniques and the structures of [1]Cl, [3]Cl and [4]Cl were determined in the solid-state by single-crystal X-ray diffraction. The antiproliferative activity of [1]Cl-[8]Cl was evaluated against human ovarian cancer (A2780, A2780cisR) and non-cancerous (HEK293) cells with [4]Cl and [5]Cl being more active than cisplatin on the cancer cells and also more selective. (C) 2014 Elsevier B.V. All rights reserved.

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https://infoscience.epfl.ch/entities/publication/7399b6bf-760e-4087-8389-63e3e2a3f9f7

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Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Noelia Claude Herrero
2014
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/7399b6bf-760e-4087-8389-63e3e2a3f9f7

About this result

Related concepts (23)

Ovarian cancer

Ovarian cancer is a cancerous tumor of an ovary. It may originate from the ovary itself or more commonly from communicating nearby structures such as fallopian tubes or the inner lining of the abdomen. The ovary is made up of three different cell types including epithelial cells, germ cells, and stromal cells. When these cells become abnormal, they have the ability to divide and form tumors. These cells can also invade or spread to other parts of the body. When this process begins, there may be no or only vague symptoms.

Cancer cell

Cancer cells are cells that divide continually, forming solid tumors or flooding the blood or lymph with abnormal cells. Cell division is a normal process used by the body for growth and repair. A parent cell divides to form two daughter cells, and these daughter cells are used to build new tissue or to replace cells that have died because of aging or damage. Healthy cells stop dividing when there is no longer a need for more daughter cells, but cancer cells continue to produce copies.

Cancer stem cell

Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types.

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