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Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex

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The functional characterization of callosal connections

The brain operates through the synaptic interaction of distant neurons within flexible, often heterogeneous, distributed systems. Histological studies have detailed the connections between distant neurons, but their functional characterization deserves fur ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Fear Learning: An Evolving Picture for Plasticity at Synaptic Afferents to the Amygdala

Ralf Schneggenburger, Shriya Palchaudhuri, Denys Osypenko

Unraveling the neuronal mechanisms of fear learning might allow neuroscientists to make links between a learned behavior and the underlying plasticity at specific synaptic connections. In fear learning, an innocuous sensory event such as a tone (called the ...

SAGE PUBLICATIONS INC2022

High synaptic threshold for dendritic NMDA spike generation in human layer 2/3 pyramidal neurons

James Gonzalo King, Suraj Honnuraiah

Neurons receive synaptic input primarily onto their dendrites. While we know much about the electrical properties of dendrites in rodents, we have only just started to describe their properties in the human brain. Here, we investigate the capacity of human ...

2022

A subpopulation of cortical VIP-expressing interneurons with highly dynamic spines

Graham Knott, Jérôme Blanc, Christina Georgiou, Kok Sin Lee

Structural synaptic plasticity may underlie experience and learning-dependent changes in cortical circuits. In contrast to excitatory pyramidal neurons, insight into the structural plasticity of inhibitory neurons remains limited. Interneurons are divided ...

NATURE PORTFOLIO2022

Mesoscopic description of hippocampal replay and metastability in spiking neural networks with short-term plasticity

Valentin Marc Schmutz, Tilo Schwalger

Bottom-up models of functionally relevant patterns of neural activity provide an explicit link between neuronal dynamics and computation. A prime example of functional activity patterns are propagating bursts of place-cell activities called hippocampal rep ...

PUBLIC LIBRARY SCIENCE2022

Pathological substrate of memory impairment in multiple system atrophy

Hilal Lashuel, Melek Firat Altay

Aims: Synaptic dysfunction in Parkinson's disease is caused by propagation of pathogenic alpha-synuclein between neurons. Previously, in multiple system atrophy (MSA), pathologically characterised by ectopic deposition of abnormal alpha-synuclein predomina ...

WILEY2022