MicrofluidicsMicrofluidics refers to a system that manipulates a small amount of fluids ((10−9 to 10−18 liters) using small channels with sizes ten to hundreds micrometres. It is a multidisciplinary field that involves molecular analysis, biodefence, molecular biology, and microelectronics. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening.
Droplet-based microfluidicsDroplet-based microfluidics manipulate discrete volumes of fluids in immiscible phases with low Reynolds number and laminar flow regimes. Interest in droplet-based microfluidics systems has been growing substantially in past decades. Microdroplets offer the feasibility of handling miniature volumes (μl to fl) of fluids conveniently, provide better mixing, encapsulation, sorting, sensing and are suitable for high throughput experiments.
Paper-based microfluidicsPaper-based microfluidics are microfluidic devices that consist of a series of hydrophilic cellulose or nitrocellulose fibers that transport fluid from an inlet through the porous medium to a desired outlet or region of the device, by means of capillary action. This technology builds on the conventional lateral flow test which is capable of detecting many infectious agents and chemical contaminants. The main advantage of this is that it is largely a passively controlled device unlike more complex microfluidic devices.
Lab-on-a-chipA lab-on-a-chip (LOC) is a device that integrates one or several laboratory functions on a single integrated circuit (commonly called a "chip") of only millimeters to a few square centimeters to achieve automation and high-throughput screening. LOCs can handle extremely small fluid volumes down to less than pico-liters. Lab-on-a-chip devices are a subset of microelectromechanical systems (MEMS) devices and sometimes called "micro total analysis systems" (μTAS). LOCs may use microfluidics, the physics, manipulation and study of minute amounts of fluids.
Organ-on-a-chipAn organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context.
Hydraulic machineryHydraulic machines use liquid fluid power to perform work. Heavy construction vehicles are a common example. In this type of machine, hydraulic fluid is pumped to various hydraulic motors and hydraulic cylinders throughout the machine and becomes pressurized according to the resistance present. The fluid is controlled directly or automatically by control valves and distributed through hoses, tubes, or pipes.
Hydraulic fluidA hydraulic fluid or hydraulic liquid is the medium by which power is transferred in hydraulic machinery. Common hydraulic fluids are based on mineral oil or water. Examples of equipment that might use hydraulic fluids are excavators and backhoes, hydraulic brakes, power steering systems, automatic transmissions, garbage trucks, aircraft flight control systems, lifts, and industrial machinery. Hydraulic systems like the ones mentioned above will work most efficiently if the hydraulic fluid used has zero compressibility.
Loading gaugeA loading gauge is a diagram or physical structure that defines the maximum height and width dimensions in railway vehicles and their loads. Their purpose is to ensure that rail vehicles can pass safely through tunnels and under bridges, and keep clear of platforms, trackside buildings and structures. Classification systems vary between different countries, and gauges may vary across a network, even if the track gauge is uniform.
Position (geometry)In geometry, a position or position vector, also known as location vector or radius vector, is a Euclidean vector that represents the position of a point P in space in relation to an arbitrary reference origin O. Usually denoted x, r, or s, it corresponds to the straight line segment from O to P. In other words, it is the displacement or translation that maps the origin to P: The term position vector is used mostly in the fields of differential geometry, mechanics and occasionally vector calculus.
Coulter counterA Coulter counter is an apparatus for counting and sizing particles suspended in electrolytes. The Coulter counter is the commercial term for the technique known as resistive pulse sensing or electrical zone sensing. The apparatus is based on the Coulter principle named after its inventor, Wallace H. Coulter. A typical Coulter counter has one or more microchannels that separate two chambers containing electrolyte solutions. As fluid that contains particles or cells is drawn through the microchannels, each particle causes a brief change to the electrical resistance of the liquid.
DimensionIn physics and mathematics, the dimension of a mathematical space (or object) is informally defined as the minimum number of coordinates needed to specify any point within it. Thus, a line has a dimension of one (1D) because only one coordinate is needed to specify a point on it - for example, the point at 5 on a number line. A surface, such as the boundary of a cylinder or sphere, has a dimension of two (2D) because two coordinates are needed to specify a point on it - for example, both a latitude and longitude are required to locate a point on the surface of a sphere.
Petroleum reservoirA petroleum reservoir or oil and gas reservoir is a subsurface accumulation of hydrocarbons contained in porous or fractured rock formations. Such reservoirs form when kerogen (ancient plant matter) is created in surrounding rock by the presence of high heat and pressure in the Earth's crust. Petroleum reservoirs are broadly classified as conventional and unconventional reservoirs.
Reservoir engineeringReservoir engineering is a branch of petroleum engineering that applies scientific principles to the fluid flow through a porous medium during the development and production of oil and gas reservoirs so as to obtain a high economic recovery. The working tools of the reservoir engineer are subsurface geology, applied mathematics, and the basic laws of physics and chemistry governing the behavior of liquid and vapor phases of crude oil, natural gas, and water in reservoir rock.
Hydraulic brakeA hydraulic brake is an arrangement of braking mechanism which uses brake fluid, typically containing glycol ethers or diethylene glycol, to transfer pressure from the controlling mechanism to the braking mechanism. During 1904, Frederick George Heath (Heath Hydraulic Brake Co., Ltd.), Redditch, England devised and fitted a hydraulic (water/glycerine) brake system to a cycle using a handlebar lever and piston. He obtained patent GB190403651A for “Improvements in hydraulic actuated brakes for cycles and motors”, as well as subsequently for improved flexible rubber hydraulic pipes.
Hydraulic analogyElectronic-hydraulic analogies are the representation of electronic circuits by hydraulic circuits. Since electric current is invisible and the processes in play in electronics are often difficult to demonstrate, the various electronic components are represented by hydraulic equivalents. Electricity (as well as heat) was originally understood to be a kind of fluid, and the names of certain electric quantities (such as current) are derived from hydraulic equivalents.
Hydraulic headHydraulic head or piezometric head is a specific measurement of liquid pressure above a vertical datum. It is usually measured as a liquid surface elevation, expressed in units of length, at the entrance (or bottom) of a piezometer. In an aquifer, it can be calculated from the depth to water in a piezometric well (a specialized water well), and given information of the piezometer's elevation and screen depth. Hydraulic head can similarly be measured in a column of water using a standpipe piezometer by measuring the height of the water surface in the tube relative to a common datum.
Ion channelIon channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, the other being ion transporters.
Hydraulic conductivityIn science and engineering, hydraulic conductivity (K, in SI units of meters per second), is a property of porous materials, soils and rocks, that describes the ease with which a fluid (usually water) can move through the pore space, or fractures network. It depends on the intrinsic permeability (k, unit: m^2) of the material, the degree of saturation, and on the density and viscosity of the fluid. Saturated hydraulic conductivity, Ksat, describes water movement through saturated media.
Track gaugeIn rail transport, track gauge (in American English, alternatively track gage) is the distance between the two rails of a railway track. All vehicles on a rail network must have wheelsets that are compatible with the track gauge. Since many different track gauges exist worldwide, gauge differences often present a barrier to wider operation on railway networks. The term derives from the metal bar, or gauge, that is used to ensure the distance between the rails is correct.
Voltage-gated potassium channelVoltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in the cell's membrane potential. During action potentials, they play a crucial role in returning the depolarized cell to a resting state. Alpha subunits form the actual conductance pore. Based on sequence homology of the hydrophobic transmembrane cores, the alpha subunits of voltage-gated potassium channels are grouped into 12 classes. These are labeled Kvα1-12.
