Publication

Antiproliferative Activity of Gold(I) Alkyne Complexes Containing Water-Soluble Phosphane Ligands

Paul Joseph Dyson, Angela Casini, Olivier Pierre Zava, elena vergara
2010
Journal Articles

Abstract

A series of mono-, di-, and trinuclear organometallic alkynyl phosphane gold(I) complexes contg. the stable and water-sol. PTA and DAPTA ligands have been synthesized and characterized. The solid-state structure of one of these compds. was also established by x-ray crystallog. Luminescence was obsd. for most of these Au(I) alkynyl derivs. in the solid state. The cytotoxicity of the complexes was evaluated on A2780 ovarian cancer cells and on their cisplatin-resistant cell line A2780cisR; the compds. showed an activity in the low μM range, being markedly more active than cisplatin in the A2780cisR cell line. The intracellular distribution of some representative compds. was detd. using epifluorescence microscopy. The presented results are discussed in relation to the putative mechanism of action of this family of gold-based cytotoxic agents.

Official source

https://infoscience.epfl.ch/entities/publication/8aadbdc9-848f-4c84-be44-577c5032c461

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Paul Joseph Dyson, Angela Casini, Olivier Pierre Zava, elena vergara
2010
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/8aadbdc9-848f-4c84-be44-577c5032c461

About this result

Related concepts (17)

Solid-state physics

Solid-state physics is the study of rigid matter, or solids, through methods such as solid-state chemistry, quantum mechanics, crystallography, electromagnetism, and metallurgy. It is the largest branch of condensed matter physics. Solid-state physics studies how the large-scale properties of solid materials result from their atomic-scale properties. Thus, solid-state physics forms a theoretical basis of materials science. Along with solid-state chemistry, it also has direct applications in the technology of transistors and semiconductors.

Solid-state chemistry

Solid-state chemistry, also sometimes referred as materials chemistry, is the study of the synthesis, structure, and properties of solid phase materials. It therefore has a strong overlap with solid-state physics, mineralogy, crystallography, ceramics, metallurgy, thermodynamics, materials science and electronics with a focus on the synthesis of novel materials and their characterization. A diverse range of synthetic techniques, such as the ceramic method and chemical vapour depostion, make solid-state materials.

Gold

Gold is a chemical element with the symbol Au () and atomic number 79. It is a bright, slightly orange-yellow, dense, soft, malleable, and ductile metal in pure form. Chemically, gold is a transition metal and a group 11 element. It is one of the least reactive chemical elements and is solid under standard conditions. Gold often occurs in free elemental (native state), as nuggets or grains, in rocks, veins, and alluvial deposits.

Related publications (32)

Automatic and high-precision microseismic monitoring of progressive failure prior, during, and after tunnel excavation

Brice Tanguy Alphonse Lecampion, Christophe Nussbaum, Seyyedmaalek Momeni

Acoustic emission (AE) monitoring is commonly used to inspect the health of a structure continuously. During fracture processes elastic waves of AE are created and emitted, and sensors can capture these waves. The acquired signals can be processed to track ...

2023

koopmans: An Open-Source Package for Accurately and Efficiently Predicting Spectral Properties with Koopmans Functionals

Nicola Marzari, Giovanni Borghi, Ngoc Linh Nguyen, Nicola Colonna, Riccardo De Gennaro, Edward Baxter Linscott, Andrea Ferretti

Over the past decade we have developed Koopmans functionals, a computationally efficient approach for predicting spectral properties with an orbital-density-dependent functional framework. These functionals impose a generalized piecewise linearity conditio ...

Amer Chemical Soc2023

Vibrational NDT with Under-sampled Data through Physics-informed Neural Networks

Olga Fink

The vibrational response of solid materials and structural components is substantially governed by their mechanical and geometrical properties. Low-frequency vibrations and modal frequencies are sensitive to global geometrical deviations, while high-freque ...

2023