Publications related to Reply to comments on "Explicit versus implicit front advancing schemes for the simulation of hydraulic fracture growth" (Int. J. Numer. Anal. Methods Geomech., 2019, 43 (6), 1300-1315)" by Prof. Linkov

Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Thamyris Silva

Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...

2024

Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Thamyris Silva

Adolescent individuals exhibit great variability in cortical dynamics and behavioral outcomes. The developing adolescent brain is highly sensitive to social experiences and environmental insults, influencing how personality traits emerge. A distinct patter ...

2023

Pore-pressure coefficients for unsaturated soils: generalized effective stress approach

Lyesse Laloui, Alessio Ferrari, Angelica Tuttolomondo

Geotechnical problems with total stress changes occurring rapidly relative to the soil consolidation time can be conveniently addressed using an effective stress-based approach. For saturated states, analytical formulations of pore-pressure coefficients ad ...

CANADIAN SCIENCE PUBLISHING2023

'connEcted caesarean section': creating a virtual link between MOthers and their infanTs to ImprOve maternal childbirth experieNce - study protocol for a PILOT trial (e-motion-pilot)

Sandra Maria Marcadent, Karine Lepigeon, Fiona Corbaz, David Desseauve

IntroductionOne-third of mothers rate their childbirth as traumatic. The prevalence of childbirth-related post-traumatic stress disorder (CB-PTSD) is 4.7%. Skin-to-skin contact is a protective factor against CB-PTSD. However, during a caesarean section (CS ...

BMJ PUBLISHING GROUP2023

Genetic selection for low glucocorticoid responsiveness recapitulates PTSD-related phenotypes: a behavioral, neuroimaging and sleep-physiology study

Silvia Monari

Humans show inter-individual differences in vulnerability to develop post-traumatic stress disorder (PTSD) following exposure to trauma. Several critical biobehavioral features have been consistently described in PTSD patients, including blunted cortisol l ...

EPFL2022

Identification of biopsychological trait markers in functional neurological disorders

Serafeim Loukas

Weber et al. provide evidence in support of a stress-diathesis model of functional neurological disorders. They identify trauma history in the form of emotional neglect as a psychological risk factor, and reduced hippocampus and amygdala volume as a predis ...

OXFORD UNIV PRESS2022

Exploring associations between diurnal cortisol, stress, coping and psychopathology in adolescents and young adults with 22q11.2 deletion syndrome

Maria del Carmen Sandi Perez, Olivia Zanoletti, Maude Schneider, Farnaz Delavari

Background: 22q11.2 deletion syndrome (22q11DS) is a neurogenetic condition associated to a high risk for psychiatric disorders, including psychosis. Individuals with 22q11DS are thought to experience increased levels of chronic stress, which could lead to ...

2022

Effective stress for unsaturated active clays and in-situ effective stress estimation methodology

Angelica Tuttolomondo

The complexity of the mechanics of active clays and, more generally, of geomaterials with clay minerals, under saturated and unsaturated conditions, still provides relevant scientific challenges today. Equally relevant challenges are the understanding of t ...

EPFL2021

Title: "Labels Matter: Is it stress or is it Trauma?"

Maria del Carmen Sandi Perez

In neuroscience, the term 'Stress' has a negative connotation because of its potential to trigger or exacerbate psychopathologies. Yet in the face of exposure to stress, the more common reaction to stress is resilience, indicating that resilience is the ru ...

SPRINGERNATURE2021

Maladaptive emotion regulation traits predict altered corticolimbic recovery from psychosocial stress

Dimitri Nestor Alice Van De Ville

Background: Adaptive recovery from stress promotes healthy cognitive affective functioning, whereas maladaptive recovery is linked to poor psychological outcomes. Neural regions, like the anterior cingulate and hippocampus, play critical roles in psychosoc ...

ELSEVIER2021

Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice

Maria del Carmen Sandi Perez

The impact of stressful events is especially important during early life, because certain cortical regions, especially the prefrontal cortex (PFC), are still developing. Consequently, aversive experiences that occur during the peripubertal period can cause ...

2021

Music influences vividness and content of imagined journeys in a directed visual imagery task

Gabriele Cecchetti, Steffen Alexander Herff, Ken Jacques Alfonso Deguernel

Directed, intentional imagination is pivotal for self-regulation in the form of escapism and therapies for a wide variety of mental health conditions, such anxiety and stress disorders, as well as phobias. Clinical application in particular benefits from i ...

Nature Portfolio2021

Programming effects of peripubertal stress on spatial learning

Maria del Carmen Sandi Perez, Cristina Marquez Vega, Stamatina Tzanoulinou

Exposure to adversity during early life can have profound influences on brain function and behavior later in life. The peripubertal period is emerging as an important time-window of susceptibility to stress, with substantial evidence documenting long-term ...

2020

A coupled hydro – mechanical approach for modelling the volume change behaviour of compacted bentonite

Lyesse Laloui, Alessio Ferrari, Jose Antonio Bosch Llufriu

The volumetric response of compacted bentonites against environmental actions is a key aspect in most designs of nuclear waste repositories. The safety assessment of such repositories must account for robust and reliable models of stress–strain for bentoni ...

EDP SCIENCES2020

Locomotion in virtual environments predicts cardiovascular responsiveness to subsequent stressful challenges

Maria del Carmen Sandi Perez, Nathalie Heidi Meyer, João Pedro de Matos Rodrigues, Stephan Streuber, Erik Hans Jakob Studer

Individuals differ in their physiological responsiveness to stressful challenges, and stress potentiates the development of many diseases. Heart rate variability (HRV), a measure of cardiac vagal break, is emerging as a strong index of physiological stress ...

Nature Research2020

Stress management in the context of induced seismicity in subsurface reservoirs

Barnaby Padraig Fryer

The stress state of the subsurface has been shown to have an influence on a number of key processes. For example, the criticality of the stress state indicates how large stress changes need to be before a fault begins to slip, the mean effective stress con ...

EPFL2020

Initial effective stress controls the nature of earthquakes

Fabian Barras, Marie Estelle Solange Violay, François Xavier Thibault Passelègue

Modern geophysics highlights that the slip behaviour response of faults is variable in space and time and can result in slow or fast ruptures. However, the origin of this variation of the rupture velocity in nature as well as the physics behind it is still ...

Nature Research2020

Hydraulic Transport Through Calcite Bearing Faults With Customized Roughness: Effects of Normal and Shear Loading

Marie Estelle Solange Violay, Mateo Alejandro Acosta

Understanding fluid flow in rough fractures is of high importance to large scale geologic processes and to most anthropogenic geo‐energy activities. Here we conducted fluid transport experiments on Carrara marble fractures with a novel customized surface t ...

2020

Neutron Diffraction and Diffraction Contrast Imaging for Mapping the TRIP Effect under Load Path Change

Helena Van Swygenhoven, Efthymios Polatidis, Markus Strobl

The transformation induced plasticity (TRIP) effect is investigated during a load path change using a cruciform sample. The transformation properties are followed by in-situ neutron diffraction derived from the central area of the cruciform sample. Additio ...

MDPI2020

Anisotropic behaviour of shallow opalinus clay

Lyesse Laloui, Alessio Ferrari, Alberto Minardi, Eleonora Crisci

Opalinus Clay shale, the selected host geomaterial of a high-level radioactive waste repository in Switzerland, was sourced at shallow depth in a borehole in the northern part of the country. Pairs of specimens, retrieved from the same depth were prepared ...

Springer Verlag2019