Publication

Kinetics of Yttrium-Ligand Complexation Monitored Using Hyperpolarized 89Y as a Model for Gadolinium in Contrast Agents

Geoffrey Bodenhausen, Lothar Helm, Pascal Miéville, Sami Jannin
2010
Journal Articles

Abstract

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) enhances Y-89 spin magnetization by 3 to 4 orders of magnitude and provides a way to monitor yttrium-ligand complexation "on the fly" by means of Y-89 NMR. In this communication, we show an example of free yttrium Y3+ being complexed with 1,4,7,10-tetrakis(acetamido)-1,4,7,10-tetraazacyclododecane (DOTAM) to form Y(DOTAM)(H2O) as a model for gadolinium in contrast agents.

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https://infoscience.epfl.ch/entities/publication/a4aaae7b-c483-4eb2-bb02-8a1d27461ba0

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Geoffrey Bodenhausen, Lothar Helm, Pascal Miéville, Sami Jannin
2010
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/a4aaae7b-c483-4eb2-bb02-8a1d27461ba0

About this result

Related concepts (10)

Rare-earth element

The rare-earth elements (REE), also called the rare-earth metals or rare earths or, in context, rare-earth oxides, and sometimes the lanthanides (although yttrium and scandium, which do not belong to this series, are usually included as rare earths), are a set of 17 nearly indistinguishable lustrous silvery-white soft heavy metals. Compounds containing rare earths have diverse applications in electrical and electronic components, lasers, glass, magnetic materials, and industrial processes.

Yttrium

Yttrium is a chemical element with the symbol Y and atomic number 39. It is a silvery-metallic transition metal chemically similar to the lanthanides and has often been classified as a "rare-earth element". Yttrium is almost always found in combination with lanthanide elements in rare-earth minerals and is never found in nature as a free element. 89Y is the only stable isotope and the only isotope found in the Earth's crust. The most important present-day use of yttrium is as a component of phosphors, especially those used in LEDs.

Terbium

Terbium is a chemical element with the symbol Tb and atomic number 65. It is a silvery-white, rare earth metal that is malleable, and ductile. The ninth member of the lanthanide series, terbium is a fairly electropositive metal that reacts with water, evolving hydrogen gas. Terbium is never found in nature as a free element, but it is contained in many minerals, including cerite, gadolinite, monazite, xenotime and euxenite. Swedish chemist Carl Gustaf Mosander discovered terbium as a chemical element in 1843.

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