Publication

Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control

Jacques Fellay, Amalio Telenti, Istvan Bartha, Paul Jack Mc Laren
2017
Journal Articles

Abstract

We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.

Official source

https://infoscience.epfl.ch/entities/publication/a4bdc467-244d-4615-b8c5-44e743cd0a75

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Jacques Fellay, Amalio Telenti, Istvan Bartha, Paul Jack Mc Laren
2017
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/a4bdc467-244d-4615-b8c5-44e743cd0a75

About this result

Related concepts (28)

Viral load

Viral load, also known as viral burden, is a numerical expression of the quantity of virus in a given volume of fluid, including biological and environmental specimens. It is not to be confused with viral titre or viral titer, which depends on the assay. When an assay for measuring the infective virus particle is done (Plaque assay, Focus assay), viral titre often refers to the concentration of infectious viral particles, which is different from the total viral particles. Viral load is measured using body fluids Sputum and blood plasma.

Genetic variation

Genetic variation is the difference in DNA among individuals or the differences between populations among the same species. The multiple sources of genetic variation include mutation and genetic recombination. Mutations are the ultimate sources of genetic variation, but other mechanisms, such as genetic drift, contribute to it, as well. Genetic variation can be identified at many levels. Identifying genetic variation is possible from observations of phenotypic variation in either quantitative traits (traits that vary continuously and are coded for by many genes (e.

HIV

The human immunodeficiency viruses (HIV) are two species of Lentivirus (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype.

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