Publication

Consideration of the effect of the anesthesia in the thalamocortical assemblies

Martin Hasler, Kumiko Oshima, Borja Ibarz Gabardos
2007
Conference Papers

Abstract

Despite intensive research efforts, the effects of anesthesia on brain physiology and function have not been satisfactorily explained yet. Nevertheless, from what has been discovered up to now, we can attribute the effect of the anesthetics to changes in calcium(Ca2+) channels and in Gamma-aminobutyric acid type A(GABAA) synaptic receptors. In this paper, we investigate through simulations the consequences of such changes in a Hodgkin-Huxley-based model of thalamocortical assemblies.

Official source

https://infoscience.epfl.ch/entities/publication/a7c51d9c-4ef4-4e5d-8eaf-66601548f3eb

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Martin Hasler, Kumiko Oshima, Borja Ibarz Gabardos
2007
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/a7c51d9c-4ef4-4e5d-8eaf-66601548f3eb

About this result

Related concepts (12)

Synaptic plasticity

In neuroscience, synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity. Since memories are postulated to be represented by vastly interconnected neural circuits in the brain, synaptic plasticity is one of the important neurochemical foundations of learning and memory (see Hebbian theory). Plastic change often results from the alteration of the number of neurotransmitter receptors located on a synapse.

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The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate (iGluR) that mediates fast synaptic transmission in the central nervous system (CNS). It has been traditionally classified as a non-NMDA-type receptor, along with the kainate receptor. Its name is derived from its ability to be activated by the artificial glutamate analog AMPA.

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Chemical synapses are biological junctions through which neurons' signals can be sent to each other and to non-neuronal cells such as those in muscles or glands. Chemical synapses allow neurons to form circuits within the central nervous system. They are crucial to the biological computations that underlie perception and thought. They allow the nervous system to connect to and control other systems of the body. At a chemical synapse, one neuron releases neurotransmitter molecules into a small space (the synaptic cleft) that is adjacent to another neuron.

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