Publication

Flexible Optoelectric Neural Interface Integrated Wire-Bonding mu LEDs and Microelectrocorticography for Optogenetics

Xiaoyang Kang, Xiaolin Wang, Xiaowei Gu
2017
Journal Articles

Abstract

As an advanced brain-computer interface, the flexible surface electrodearrayhas been used for spatiotemporal localization of neural interactions by recording electrocorticography (ECoG) signals over brain cortical areas. Compared with the electrical stimulation, optogenetics provides a potentially ideal way to stimulate the genetically modified brain tissue by light. In this paper, we developed an optoelectric neural interface combining a micro ECoG (mu ECoG) recording electrode array and amicrolight-emitting diode (mu LED) array. Three mu LED chips were connected to a flexible polyimide substrate by a unique wire bonding method, and their light-emitting surfaces were downward and in the same plane with the substrate's lower surface, which allowed blue light directly going through the aligned holes on substrate with barely no loss. In addition, the recording electrodes were modified with electroplated platinum black or activated iridium oxide, and their stability was proved well after repetitive pressures. Mechanical strength and conformality of two mu ECoG arrays with 5 and 10 mu m thicknesses were tested. Finally, this bidirectional neural interface was proved to be effective by an acute in vivo experiment performed by attaching two devices with varied thicknesses to the cortical surface of a mouse expressing Channelrhodopsin-2.

Official source

https://infoscience.epfl.ch/entities/publication/bde21d00-415a-4bed-8d1a-996cfcaa5ca4

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Xiaoyang Kang, Xiaolin Wang, Xiaowei Gu
2017
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/bde21d00-415a-4bed-8d1a-996cfcaa5ca4

About this result

Related concepts (24)

Brain–computer interface

A brain–computer interface (BCI), sometimes called a brain–machine interface (BMI) or smartbrain, is a direct communication pathway between the brain's electrical activity and an external device, most commonly a computer or robotic limb. BCIs are often directed at researching, mapping, assisting, augmenting, or repairing human cognitive or sensory-motor functions. They are often conceptualized as a human–machine interface that skips the intermediary component of the physical movement of body parts, although they also raise the possibility of the erasure of the discreteness of brain and machine.

Electroencephalography

Electroencephalography (EEG) is a method to record an electrogram of the spontaneous electrical activity of the brain. The biosignals detected by EEG have been shown to represent the postsynaptic potentials of pyramidal neurons in the neocortex and allocortex. It is typically non-invasive, with the EEG electrodes placed along the scalp (commonly called "scalp EEG") using the International 10–20 system, or variations of it. Electrocorticography, involving surgical placement of electrodes, is sometimes called "intracranial EEG".

Electrocorticography

Electrocorticography (ECoG), a type of intracranial electroencephalography (iEEG), is a type of electrophysiological monitoring that uses electrodes placed directly on the exposed surface of the brain to record electrical activity from the cerebral cortex. In contrast, conventional electroencephalography (EEG) electrodes monitor this activity from outside the skull. ECoG may be performed either in the operating room during surgery (intraoperative ECoG) or outside of surgery (extraoperative ECoG).

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