Protein–protein interactionProtein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect. Many are physical contacts with molecular associations between chains that occur in a cell or in a living organism in a specific biomolecular context. Proteins rarely act alone as their functions tend to be regulated.
Complex networkIn the context of network theory, a complex network is a graph (network) with non-trivial topological features—features that do not occur in simple networks such as lattices or random graphs but often occur in networks representing real systems. The study of complex networks is a young and active area of scientific research (since 2000) inspired largely by empirical findings of real-world networks such as computer networks, biological networks, technological networks, brain networks, climate networks and social networks.
Complex systemA complex system is a system composed of many components which may interact with each other. Examples of complex systems are Earth's global climate, organisms, the human brain, infrastructure such as power grid, transportation or communication systems, complex software and electronic systems, social and economic organizations (like cities), an ecosystem, a living cell, and ultimately the entire universe.
Higher-order functionIn mathematics and computer science, a higher-order function (HOF) is a function that does at least one of the following: takes one or more functions as arguments (i.e. a procedural parameter, which is a parameter of a procedure that is itself a procedure), returns a function as its result. All other functions are first-order functions. In mathematics higher-order functions are also termed operators or functionals. The differential operator in calculus is a common example, since it maps a function to its derivative, also a function.
Network scienceNetwork science is an academic field which studies complex networks such as telecommunication networks, computer networks, biological networks, cognitive and semantic networks, and social networks, considering distinct elements or actors represented by nodes (or vertices) and the connections between the elements or actors as links (or edges). The field draws on theories and methods including graph theory from mathematics, statistical mechanics from physics, data mining and information visualization from computer science, inferential modeling from statistics, and social structure from sociology.
Climate as complex networksThe field of complex networks has emerged as an important area of science to generate novel insights into nature of complex systems The application of network theory to climate science is a young and emerging field. To identify and analyze patterns in global climate, scientists model climate data as complex networks. Unlike most real-world networks where nodes and edges are well defined, in climate networks, nodes are identified as the sites in a spatial grid of the underlying global climate data set, which can be represented at various resolutions.
Network theoryIn mathematics, computer science and network science, network theory is a part of graph theory. It defines networks as graphs where the nodes or edges possess attributes. Network theory analyses these networks over the symmetric relations or asymmetric relations between their (discrete) components. Network theory has applications in many disciplines, including statistical physics, particle physics, computer science, electrical engineering, biology, archaeology, linguistics, economics, finance, operations research, climatology, ecology, public health, sociology, psychology, and neuroscience.
Simplicial complexIn mathematics, a simplicial complex is a set composed of points, line segments, triangles, and their n-dimensional counterparts (see illustration). Simplicial complexes should not be confused with the more abstract notion of a simplicial set appearing in modern simplicial homotopy theory. The purely combinatorial counterpart to a simplicial complex is an abstract simplicial complex. To distinguish a simplicial complex from an abstract simplicial complex, the former is often called a geometric simplicial complex.
Social networkA social network is a social structure made up of a set of social actors (such as individuals or organizations), sets of dyadic ties, and other social interactions between actors. The social network perspective provides a set of methods for analyzing the structure of whole social entities as well as a variety of theories explaining the patterns observed in these structures. The study of these structures uses social network analysis to identify local and global patterns, locate influential entities, and examine network dynamics.
Social network analysisSocial network analysis (SNA) is the process of investigating social structures through the use of networks and graph theory. It characterizes networked structures in terms of nodes (individual actors, people, or things within the network) and the ties, edges, or links (relationships or interactions) that connect them. Examples of social structures commonly visualized through social network analysis include social media networks, meme spread, information circulation, friendship and acquaintance networks, peer learner networks, business networks, knowledge networks, difficult working relationships, collaboration graphs, kinship, disease transmission, and sexual relationships.
Abstract simplicial complexIn combinatorics, an abstract simplicial complex (ASC), often called an abstract complex or just a complex, is a family of sets that is closed under taking subsets, i.e., every subset of a set in the family is also in the family. It is a purely combinatorial description of the geometric notion of a simplicial complex. For example, in a 2-dimensional simplicial complex, the sets in the family are the triangles (sets of size 3), their edges (sets of size 2), and their vertices (sets of size 1).
Simplicial setIn mathematics, a simplicial set is an object composed of simplices in a specific way. Simplicial sets are higher-dimensional generalizations of directed graphs, partially ordered sets and . Formally, a simplicial set may be defined as a contravariant functor from the to the . Simplicial sets were introduced in 1950 by Samuel Eilenberg and Joseph A. Zilber. Every simplicial set gives rise to a "nice" topological space, known as its geometric realization.
Non-covalent interactionIn chemistry, a non-covalent interaction differs from a covalent bond in that it does not involve the sharing of electrons, but rather involves more dispersed variations of electromagnetic interactions between molecules or within a molecule. The chemical energy released in the formation of non-covalent interactions is typically on the order of 1–5 kcal/mol (1000–5000 calories per 6.02 molecules). Non-covalent interactions can be classified into different categories, such as electrostatic, π-effects, van der Waals forces, and hydrophobic effects.
Programming paradigmProgramming paradigms are a way to classify programming languages based on their features. Languages can be classified into multiple paradigms. Some paradigms are concerned mainly with implications for the execution model of the language, such as allowing side effects, or whether the sequence of operations is defined by the execution model. Other paradigms are concerned mainly with the way that code is organized, such as grouping a code into units along with the state that is modified by the code.
Dynamic network analysisDynamic network analysis (DNA) is an emergent scientific field that brings together traditional social network analysis (SNA), link analysis (LA), social simulation and multi-agent systems (MAS) within network science and network theory. Dynamic networks are a function of time (modeled as a subset of the real numbers) to a set of graphs; for each time point there is a graph. This is akin to the definition of dynamical systems, in which the function is from time to an ambient space, where instead of ambient space time is translated to relationships between pairs of vertices.
Complex adaptive systemA complex adaptive system is a system that is complex in that it is a dynamic network of interactions, but the behavior of the ensemble may not be predictable according to the behavior of the components. It is adaptive in that the individual and collective behavior mutate and self-organize corresponding to the change-initiating micro-event or collection of events. It is a "complex macroscopic collection" of relatively "similar and partially connected micro-structures" formed in order to adapt to the changing environment and increase their survivability as a macro-structure.
Van der Waals forceIn molecular physics, the van der Waals force is a distance-dependent interaction between atoms or molecules. Unlike ionic or covalent bonds, these attractions do not result from a chemical electronic bond; they are comparatively weak and therefore more susceptible to disturbance. The van der Waals force quickly vanishes at longer distances between interacting molecules. Named after Dutch physicist Johannes Diderik van der Waals, the van der Waals force plays a fundamental role in fields as diverse as supramolecular chemistry, structural biology, polymer science, nanotechnology, surface science, and condensed matter physics.
Fold (higher-order function)In functional programming, fold (also termed reduce, accumulate, aggregate, compress, or inject) refers to a family of higher-order functions that analyze a recursive data structure and through use of a given combining operation, recombine the results of recursively processing its constituent parts, building up a return value. Typically, a fold is presented with a combining function, a top node of a data structure, and possibly some default values to be used under certain conditions.
Simplicial homologyIn algebraic topology, simplicial homology is the sequence of homology groups of a simplicial complex. It formalizes the idea of the number of holes of a given dimension in the complex. This generalizes the number of connected components (the case of dimension 0). Simplicial homology arose as a way to study topological spaces whose building blocks are n-simplices, the n-dimensional analogs of triangles. This includes a point (0-simplex), a line segment (1-simplex), a triangle (2-simplex) and a tetrahedron (3-simplex).
