Publications related to Sequestration, Scholarship, Sentinel: The Post-Politics of Peace (and War)

Patents, War and Peace. The resilience of the international patent order through the First World War

By the end of the 19th century, an international order had emerged for patents, allowing business actors to use patents in many countries concurrently, and thus supporting a new phase in the development of industrial capitalism. Centered on Europe in spite ...

2023

Enhancing Robustness of Adhesive Hydrogels through PEG-NHS Incorporation

Dominique Pioletti, François Gorostidi, Theofanis Stampoultzis, Yanheng Guo, Ece Uslu, Vijay Kumar Rana

Tissue wounds are a significant challenge for the healthcare system, affecting millions globally. Current methods like suturing and stapling have limitations as they inadequately cover the wound, fail to prevent fluid leakage, and increase the risk of infe ...

Amer Chemical Soc2023

Key Qualities of Conversational Chatbots - the PEACE Model

Pearl Pu Faltings, Ekaterina Svikhnushina

Open-domain chatbots engage in natural conversations with the user to socialize and establish bonds. However, designing and developing an effective open-domain chatbot is challenging. It is unclear what qualities of such chatbots most correspond to users' ...

ASSOC COMPUTING MACHINERY2021

Engineered peptide macrocycles can inhibit matrix metalloproteinases with high selectivity

Christian Heinis, Jeremy Touati, Maola Khan Mohammad Golam, Michal Sabisz, Alice Baumann, Jonas Alfred Karl Wilbs, Xudong Kong, Kaycie Marie Butler

Matrix metalloproteinases (MMPs) are zinc‐dependent endopeptidases at the intersection of health and disease due to their involvement in processes such as tissue repair and immunity as well as cancer and inflammation. Because of the high structural conserv ...

2019

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

Priscilla Suhasna Maithili Briquez

Regenerative medicine aims to repair body tissues when natural mechanisms fail. Growth factors (GFs) are essential proteins that promote tissue regeneration upon injury, and as such, are very promising therapeutic drugs in regenerative medicine. Due to the ...

EPFL2016

A Current View of Functional Biomaterials for Wound Care, Molecular and Cellular Therapies

Francesco Piraino

The intricate process of wound healing involves activation of biological pathways that work in concert to regenerate a tissue microenvironment consisting of cells and external cellular matrix (ECM) with enzymes, cytokines, and growth factors. Distinct stag ...

Hindawi Publishing Corp2015

Fibronectin Binding Modulates CXCL11 Activity and Facilitates Wound Healing

Mikaël Martino, Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Marco Pisano, Federico Tortelli

Engineered biomatrices offer the potential to recapitulate the regenerative microenvironment, with important implications in tissue repair. In this context, investigation of the molecular interactions occurring between growth factors, cytokines and extrace ...

Public Library of Science2013

Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing

Mikaël Martino, Jeffrey Alan Hubbell, Mayumi Mochizuki Martino, Federico Tortelli

Although growth factors naturally exert their morphogenetic influences within the context of the extracellular matrix microenvironment, the interactions among growth factors, their receptors, and other extracellular matrix components are typically ignored ...

2011

Chronic wound healing by fetal cell therapy may be explained by differential gene profiling observed in fetal versus old skin cells

Dominique Pioletti, Nathalie Hirt-Burri, Corinne Scaletta, Lee Ann Laurent-Applegate

Engineering of fetal tissue has a high potential for the treatment of acute and chronic wounds of the skin in humans as these cells have high expansion capacity under simple culture conditions and one organ donation can produce Master Cell Banks which can ...

2009

Wound healing gene-family expression differences between fetal and foreskin cells used for bioengineered skin substitutes

Dominique Pioletti, Nathalie Hirt-Burri, Corinne Scaletta, Lee Ann Laurent-Applegate

For tissue engineering, several cell types and tissues have been proposed as starting material. Allogenic skin products available for therapeutic usage are mostly developed with cell culture and with foreskin tissue of young individuals. Fetal skin cells o ...

2008

Wireless sensor networks for marginal farming in India

Jacques Panchard

In this dissertation, we explore the potential of wireless sensor networks (WSNs) in an original context, the small agriculture of Developing Countries (DCs). Our goal is to confront an emerging technology with a concrete problem of world-wide dimensions, ...

EPFL2008

Wound repair and regeneration

Yann Barrandon

The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonl ...

2008