Publications related to Synthesis, Biological Evaluation and Docking Studies of Casuarine Analogues: Effects of Structural Modifications at Ring B on Inhibitory Activity Towards Glucoamylase

IMPROVED REGULARITY OF SECOND DERIVATIVES FOR SUBHARMONIC FUNCTIONS

Riccardo Tione, Xavier Fernandez-Real Girona

In this note, we prove that if a subharmonic function Delta u >= 0 has pure second derivatives partial derivative(ii)u that are signed measures, then their negative part (partial derivative(ii)u)- belongs to L-1 (in particular, it is not singular). We then ...

Amer Mathematical Soc2023

Synthesis and Applications of Ynimines and Enantioselective Total Synthesis of Artatrovirenol A

Rémi Hugo Lavernhe

The first chapter of this thesis describe the development of a general synthesis of ynimines, an under-exploited motif in organic chemistry. In the presence of an inexpensive copper catalyst and 2,2'-biquinoline, reaction of easily accessible O-acyloximes ...

EPFL2023

TiCl3-Mediated Reductive Cyclization of Tetrasubstituted Alkenes and Enol Esters Bearing a 2-Nitrophenyl Substituent

Dina Boyarskaya

Indole is one of the most important heterocycles widely present in bioactive natural products, pharmaceuticals, agrochemicals and materials. Being easily accessible, the 2-nitrostyrenes are attractive starting materials for the indole synthesis and the Cad ...

EPFL2023

Streamlined Alkylation via Nickel-Hydride-Catalyzed Hydrocarbonation of Alkenes

Xile Hu, Zhikun Zhang, Srikrishna Bera, Chao Fan

Compounds rich in sp(3)-hybridized carbons are desirable in drug discovery. Nickel-catalyzed hydrocarbonation of alkenes is a potentially efficient method to synthesize these compounds. By using abundant, readily available, and stable alkenes as pro-nucleo ...

2022

Stochastic derivative estimation for max-stable random fields

Erwan Fabrice Koch

We consider expected performances based on max-stable random fields and we are interested in their derivatives with respect to the spatial dependence parameters of those fields. Max-stable fields, such as the Brown-Resnick and Smith fields, are very popula ...

ELSEVIER2022

Modular Synthesis of Benzocyclobutenes via Pd(II)-Catalyzed Oxidative [2+2] Annulation of Arylboronic Acids with Alkenes

Anne-Clémence Corminboeuf, Qian Wang, Jieping Zhu, Simone Gallarati, Takuji Fujii

Benzocyclobutenes (BCBs) are highly valuable compounds in organic synthesis, medicinal chemistry, and materials science. However, catalytic modular synthesis of functionalized BCBs from easily accessible starting materials remains limited. We report herein ...

2022

Learning of Continuous and Piecewise-Linear Functions With Hessian Total-Variation Regularization

Michaël Unser, Joaquim Gonçalves Garcia Barreto Campos, Shayan Aziznejad

We develop a novel 2D functional learning framework that employs a sparsity-promoting regularization based on second-order derivatives. Motivated by the nature of the regularizer, we restrict the search space to the span of piecewise-linear box splines shi ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Asymmetric Total Synthesis of Indole Alkaloids (+)-Condyfoline, (-)-Tubifoline, (+)-Dasycarpidone and (+)-Uleine

Bastien Delayre

The development of a titanium(III)-mediated cascade electrocyclisation/rearrangement for the enantioselective total synthesis of indole alkaloids (+)-condyfoline and (-)-tubifoline serve as the basis of the first chapter of this thesis. An introduction wil ...

EPFL2022

A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives

Vassily Hatzimanikatis, Jasmin Maria Hafner

Plant natural products (PNPs) and their derivatives are important but underexplored sources of pharmaceutical molecules. To access this untapped potential, the reconstitution of heterologous PNP biosynthesis pathways in engineered microbes provides a valua ...

Nature Research2021

Polarity Of Almost All Points For Systems Of Nonlinear Stochastic Heat Equations In The Critical Dimension

Robert Dalang

We study vector-valued solutions u(t, x) is an element of R-d to systems of nonlinear stochastic heat equations with multiplicative noise, ...

INST MATHEMATICAL STATISTICS-IMS2021

Structural basis of drug recognition by the multidrug transporter ABCG2

Henning Paul-Julius Stahlberg, Dongchun Ni

ABCG2 is an ATP-binding cassette (ABC) transporter whose function affects the pharmacokinetics of drugs and contributes to multidrug resistance of cancer cells. While its interaction with the endogenous substrate estrone-3-sulfate (E1S) has been elucidated ...

Elsevier2021

On design strategies for binary dielectric metasurfaces based on the Fourier modal method

Kévin Müller

Binary dielectric metasurfaces are arrays of sub-wavelength structures that act as a thin layer of artificial material. They are generally lossless and relatively simple to fabricate since only a single structuring step is required. By carefully designing ...

EPFL2020

Local Non-Rigid Structure-from-Motion from Locally Diffeomorphic Mappings

Pascal Fua, Mathieu Salzmann, Shaifali Parashar

We propose a new formulation to the non-rigid structure-from-motion problem that only requires the deforming surface to meaning that its differential structure is preserved. This is a much weaker assumption than the traditional ones of isometry or conforma ...

2020

A critically degenerate elliptic Dirichlet problem, spectral theory and bifurcation

Charles Stuart

In an open, bounded subset Omega of R-N such that 0 is an element of Omega we consider the nonlinear eigenvalue problem -Sigma(N)(i,j,=1) partial derivative(i){A(ij)(x)partial derivative(j)u} + V(x)u + n(x,del u)+ g(x, u) = lambda u in Omega integral(Omega ...

2020

Sustainability through reuse: a reconfigurable structural system for residential and office buildings

Dario Redaelli, Corentin Jean Dominique Fivet, Jan Friedrich Georg Brütting, Alex-Manuel Muresan

Current load-bearing systems for buildings rarely have a beneficial end of life. Modular design is a proven solution for revalorizing obsolete structures, but it hardly competes with conventional solutions: the range of future spatial configurations that t ...

World Sustainable Built Environment2020

On the choice of metric in gradient-based theories of brain function

Wulfram Gerstner, Jean-Pascal Théodor Pfister, Johanni Michael Brea

The idea that the brain functions so as to minimize certain costs pervades theoretical neuroscience. Because a cost function by itself does not predict how the brain finds its minima, additional assumptions about the optimization method need to be made to ...

2020

A Structural Design Methodology for Freeform Timber Plate Structures Using Wood-Wood Connections

Anh Chi Nguyen

Over the past decades, timber has gained popularity as a sustainable building material because of the rising environmental awareness. Furthermore, the resurgence of timber has also been encouraged by the advent of the digital age during the 21st century. T ...

EPFL2020

Optimal Spline Generators for Derivative Sampling

Michaël Unser, Shayan Aziznejad, Alireza Naderi

The goal of derivative sampling is to reconstruct a signal from the samples of the function and of its first-order derivative. In this paper, we consider this problem over a shift-invariant reconstruction subspace generated by two compact-support functions ...

IEEE2019

Design, Synthesis and in vitro Controlled Release of New Adamantanodiarylketone Antimycobacterials

Stewart Cole, Anthony Vocat

In the present investigation, the synthesis, the biology and the development of matrix tablet formulations for the in vitro controlled release of new adamantane diarylketone antimycobacterial derivatives, is presented. In the skeleton of the new compounds, ...

WILEY-V C H VERLAG GMBH2019

Total Synthesis of Alstolactine A & Synthetic Studies Towards Members of Akuammiline Alkaloids

Raphaël Beltran

The work presented in this thesis focuses on the synthesis of monoterpene indole alkaloids. The first part describes the development of a general methodology to provide an enantioenriched platform, useful for the convergent synthesis of Akuammiline alkalo ...

EPFL2019