Publication

Flow simulation and hemolysis modeling for a blood centrifuge device

Mark Sawley, Michel Deville, Patric Hagmann
2013
Journal Articles

Abstract

A common blood separation technique is to accelerate the sedimentation of blood constituents by centrifugation and then collect these constituents separately. When subjected to conditions of excessive stress, hemolysis can however occur, whereby the membrane of red blood cells ruptures and free hemoglobin is released into the plasma. In this paper, results of numerical simulations of the complex turbulent flow in the collection region of a blood centrifuge device are presented. These simulation results provide a detailed qualitative evaluation of the complex physical phenomena causing hemolysis. For a quantitative analysis, a 5-parameter model is proposed for the production of hemolysis. This model has been calibrated for hemolysis occurring during the collection process using experimentally measured values for different collector geometry, hematocrit level and rotational speed of the blood centrifuge device. (C) 2013 Elsevier Ltd. All rights reserved.

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https://infoscience.epfl.ch/entities/publication/d1ca5c64-4631-44ea-b938-2820bf551bfe

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Mark Sawley, Michel Deville, Patric Hagmann
2013
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/d1ca5c64-4631-44ea-b938-2820bf551bfe

About this result

Ontological neighbourhood

Biology

Cell biology: Blood

Related concepts (29)

Hemolysis

Hemolysis or haemolysis (hiːˈmɒlɪsɪs), also known by several other names, is the rupturing (lysis) of red blood cells (erythrocytes) and the release of their contents (cytoplasm) into surrounding fluid (e.g. blood plasma). Hemolysis may occur in vivo or in vitro. One cause of hemolysis is the action of hemolysins, toxins that are produced by certain pathogenic bacteria or fungi. Another cause is intense physical exercise. Hemolysins damage the red blood cell's cytoplasmic membrane, causing lysis and eventually cell death.

Blood donation

A blood donation occurs when a person voluntarily has blood drawn and used for transfusions and/or made into biopharmaceutical medications by a process called fractionation (separation of whole blood components). Donation may be of whole blood, or of specific components directly (apheresis). Blood banks often participate in the collection process as well as the procedures that follow it. Today in the developed world, most blood donors are unpaid volunteers who donate blood for a community supply.

Blood plasma

Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension. It makes up about 55% of the body's total blood volume. It is the intravascular part of extracellular fluid (all body fluid outside cells). It is mostly water (up to 95% by volume), and contains important dissolved proteins (6–8%; e.g., serum albumins, globulins, and fibrinogen), glucose, clotting factors, electrolytes (Na+, Ca2+, Mg2+, , Cl−, etc.

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