Publication

Natural polymer-derived scaffold material and methods for production thereof

Matthias Lütolf, Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Elif Vardar, Simone Allazetta, Kalitha Pinnagoda, Eva-Maria Balet
2017
Patents

Abstract

The invention relates to a scaffold material comprising a carrier and embedded microbeads for use in tissue engineering applications such as soft tissues therapeutic treatment. The scaffold provides a short-term bulking effect coupled with a long-term functional activity. Both the carrier and the microbeads are substantially composed of natural or extracellular matrix-derived polymers, and the beads can comprise homogeneously distributed active agents, providing a regulated agent release along time. An aspect of the invention relates to a method for producing the microbeads of the invention by using an expressly designed microfluidic chip.

Official source

https://infoscience.epfl.ch/entities/publication/d36b3f07-8130-4a9b-8370-3130532e1dba

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Matthias Lütolf, Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Elif Vardar, Simone Allazetta, Kalitha Pinnagoda, Eva-Maria Balet
2017
Patents

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/d36b3f07-8130-4a9b-8370-3130532e1dba

About this result

Related concepts (9)

Tissue engineering

Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. Tissue engineering often involves the use of cells placed on tissue scaffolds in the formation of new viable tissue for a medical purpose but is not limited to applications involving cells and tissue scaffolds.

Biomaterial

A biomaterial is a substance that has been engineered to interact with biological systems for a medical purpose, either a therapeutic (treat, augment, repair, or replace a tissue function of the body) or a diagnostic one. As a science, biomaterials is about fifty years old. The study of biomaterials is called biomaterials science or biomaterials engineering. It has experienced steady and strong growth over its history, with many companies investing large amounts of money into the development of new products.

Biopolymer

Biopolymers are natural polymers produced by the cells of living organisms. Like other polymers, biopolymers consist of monomeric units that are covalently bonded in chains to form larger molecules. There are three main classes of biopolymers, classified according to the monomers used and the structure of the biopolymer formed: polynucleotides, polypeptides, and polysaccharides. The Polynucleotides, RNA and DNA, are long polymers of nucleotides. Polypeptides include proteins and shorter polymers of amino acids; some major examples include collagen, actin, and fibrin.

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