Publications related to Comparison of naphthalene bioavailability determined by whole-cell biosensing and availability determined by extraction with Tenax

Monitoring of Protein and pH Levels in Human Biofluids using FD-SOI Silicon Nanowire Arrays

Medical research and technological advancements are heading towards tailored healthcare approaches that prioritize individual needs, allowing for more accurate diagnoses, more effective treatments, and better patient outcomes overall. One such approach is ...

EPFL2023

New and improved methods for integrated models of metabolism and gene expression

Pierre Guy Rémy Salvy

The beginning of the 21st century was marked by the advent of disruptive technologies, which ushered an era of groundbreaking advances in fundamental sciences, carried by the great pace at which computational capabilities spread and evolved. But the new ce ...

EPFL2021

Data-Driven Advancement of Homogeneous Nickel Catalyst Activity for Aryl Ether Cleavage

Anne-Clémence Corminboeuf, Matthew Wodrich, Manuel Cordova, Benjamin André René Meyer, Boodsarin Sawatlon

The increasing urgency to make chemical processes more environmentally friendly while continuing to derive the chemicals required for modern society from renewable resources requires the development of a forthcoming generation of synthetic processes and th ...

AMER CHEMICAL SOC2020

Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals

Sebastian Maerkl, Francesca Volpetti, Ekaterina Emilova Petrova

Cell-based biosensors have great potential to detect various toxic and pathogenic contaminants in aqueous environments. However, frequently they cannot meet practical requirements due to insufficient sensing performance. To address this issue, we investiga ...

2019

A fish intestinal barrier model to assess the interaction with chemicals in vitro

Hannah Inka Schug

The intestinal epithelium acts as vital gate keeper between the fish and its surrounding environment. A single layer of connected epithelial cells forms a selective barrier, which, among other essential functions, is important for nutrient uptake and defen ...

EPFL2019

Quantitative chemical biosensing by bacterial chemotaxis in microfluidic chips

Harald Van Lintel, Jan Roelof van der Meer, Clémence Roggo

Whole-cell bacterial bioreporters are proposed asalternatives to chemical analysis of, for example, pol-lutants in environmental compartments. Commonlybased on reporter gene induction, bioreporters pro-duce a detectable signal within 30 min to a few hoursa ...

2018

TransFEr: a new device to measure the transfer of volatile and hydrophobic organic chemicals across an in vitro intestinal fish cell barrier

Kristin Schirmer, Hannah Inka Schug

Transfer of compounds across cellular barriers is a critical step of compound uptake into organisms. Using in vitro barrier systems to evaluate such transfer is attractive because of the higher throughput and reduced resource needs compared to animal studi ...

ROYAL SOC CHEMISTRY2018

Phytoremediation of soils contaminated by organic compounds: hype, hope and facts

Jean-Paul Schwitzguebel

The present opinion paper is focused on the phytoremediation of organic pollutants and is based on the lectures given by the author during the International Congress of Phytoremediation of Polluted Soils, held at Vigo, Spain, 29-30 July 2014. The aim of th ...

Springer Verlag2017

Direct amidation of esters with nitroarenes

Xile Hu, Chi Wai Cheung, Marten Leendert Ploeger

Esters are one of the most common functional groups in natural and synthetic products, and the one-step conversion of the ester group into other functional groups is an attractive strategy in organic synthesis. Direct amidation of esters is particularly ap ...

Nature Publishing Group2017

Ultra Selective and Sensitive Electrochemical Detection of Anti-Cancer and Anti-Viral Drugs by Optimized Nano-Bio-Sensors

Nima Aliakbarinodehi

Reliable, low cost, and accessible drug monitoring systems for individualized healthcare, especially chemotherapy for malignant diseases like prostate cancer and AIDS, are highly desira-ble. This is even more critical for drugs like abiraterone and TFV, wi ...

EPFL2017

Living on the Edge: Re-shaping the Interface of Synthetic Biology and Nanotechnology

Ardemis Anoush Boghossian, Shang-Jung Wu

A new team of researchers at EPFL is taking an 'anti-disciplinary' approach to creating optical devices. These devices take advantage of the synergy in tuning both nano- and bio-material properties, coupling 'the advantages of two growing, albeit tradition ...

Schweizerische Chemische Gesellschaft2016

A Rhodium Nanoparticle-Lewis Acidic Ionic Liquid Catalyst for the Chemoselective Reduction of Heteroarenes

Paul Joseph Dyson, Ismail Akçok, Alena Karakulina, Shoubhik Das, Aswin Gopakumar, Bastien Lucas Roulier

We describe a catalytic system composed of rhodium nanoparticles immobilized in a Lewis acidic ionic liquid. The combined system catalyzes the hydrogenation of quinolines, pyridines, benzofurans, and furan to access the corresponding heterocycles, importan ...

Wiley-VCH Verlag GmbH2016

A hyphenated SMPS-ICPMS coupling setup: Size-resolved element specific analysis of airborne nanoparticles

Christian Ludwig, Adrian Hess, Mohamed Tarik

Physical and chemical characterization of gas borne particles in the nanometer to sub micrometer size range includes knowledge about particle size distribution and chemical composition, possibly with a high time resolution. However, most of the available t ...

Elsevier Sci Ltd2015

Catalyst Development for Selective Hydrogenation of Functionalized Alkynes and Nitroarenes

Artur Yarulin

Catalyst design is of major importance for fine chemicals industry due to complexity of the synthesis and high product quality requirements. Moreover, the catalyst formulation has to comply with the standards of health, safety and environmental regulati ...

EPFL2014

Electrochemical As(III) Whole-Cell Based Biochip Sensor

Hubert Girault, Fernando Cortes Salazar

The development of a whole-cell based sensor for arsenite detection coupling biological engineering and electrochemical techniques is presented. This strategy takes advantage of the natural Escherichia coli resistance mechanism against toxic arsenic specie ...

Elsevier2013

Bioreporters and biosensors for arsenic detection. Biotechnological solutions for a world-wide pollution problem

Philippe Renaud, Nina Buffi

A wide variety of whole cell bioreporter and biosensor assays for arsenic detection has been developed over the past decade. The assays permit flexible detection instrumentation while maintaining excellent method of detection limits in the environmentally ...

Elsevier2013

Self-Assembled Electrical Biodetector Based on Reduced Graphene Oxide

Klaus Kern, Kannan Balasubramanian, Ravi Shankar Sundaram, Subramanian Sundaram

Large-scale fabrication of graphene-based devices is an aspect of great importance for various applications including chemical and biological sensing. Toward this goal, we present here a novel chemical route for the site-specific realization of devices bas ...

2012

Predicting Concentrations of Organic Chemicals in Fish by Using Toxicokinetic Models

Julita Maria Stadnicka-Michalak, Kristin Schirmer

Quantification of chemical toxicity continues to be generally based on measured external concentrations. Yet, internal chemical concentrations have been suggested to be a more suitable parameter. To better understand the relationship between the external a ...

2012

Optical Trapping in Microfluidic Channels for Functional and Chemical Analysis of Single Cells

Michael Werner

The physiological properties of cells are typically investigated in ensembles yielding averaged data that mask heterogeneities present in any cell population. Single-cell analysis techniques based on microfluidic "lab on a chip" (LOC) devices have recently ...

EPFL2011

Self-Assembled Liquid-Gated Zinc Oxide Nanowire Transistors : Fabrication and Sensing Operation

Vivek Pachauri

This thesis aims at the site-specific realization of self-assembled field-effect transistors (FETs) based on semiconducting Zinc oxide NWs and their application towards chemical and bio-sensing in liquid medium. At first, a solution based growth method for ...

EPFL2011