Publication

Photoelectric neural interface combining wire-bonding μleds with iridium oxide microelectrodes for optogenetics

Xiang Chen
2017
Conference Papers

Abstract

This paper reports the design, fabrication, electrical and thermal characterization, as well as attachment and stability of a flexible photoelectric neural interface (PENI). Upon the wire-bonding technology, three micro LED (mu LED) chips are well-connected to the polyimide substrate as an array, with their luminous surfaces over against the holes. Meanwhile, a Parylene-C-based array with four microelectrodes (200 mu m in diameter) modified by sputtering iridium oxide film is fabricated to record micro electrocorticography (mu ECoG) signals. Then, the back-to-back assembly is utilized to allow blue light through the aligned holes on both arrays with almost no attenuation. As an optogenetics tool, the PENI can be attached on the cortical surface of a mouse expressing ChR2 to realize synchronized light modulating and neural signal recording.

Official source

https://infoscience.epfl.ch/entities/publication/e1c9fade-93e3-459a-bef5-14ea539ff0e7

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Xiang Chen
2017
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/e1c9fade-93e3-459a-bef5-14ea539ff0e7

About this result

Related concepts (19)

Microelectrode array

Microelectrode arrays (MEAs) (also referred to as multielectrode arrays) are devices that contain multiple (tens to thousands) microelectrodes through which neural signals are obtained or delivered, essentially serving as neural interfaces that connect neurons to electronic circuitry. There are two general classes of MEAs: implantable MEAs, used in vivo, and non-implantable MEAs, used in vitro. Neurons and muscle cells create ion currents through their membranes when excited, causing a change in voltage between the inside and the outside of the cell.

Mu wave

The sensorimotor mu rhythm, also known as mu wave, comb or wicket rhythms or arciform rhythms, are synchronized patterns of electrical activity involving large numbers of neurons, probably of the pyramidal type, in the part of the brain that controls voluntary movement. These patterns as measured by electroencephalography (EEG), magnetoencephalography (MEG), or electrocorticography (ECoG), repeat at a frequency of 7.5–12.5 (and primarily 9–11) Hz, and are most prominent when the body is physically at rest.

Single-unit recording

In neuroscience, single-unit recordings (also, single-neuron recordings) provide a method of measuring the electro-physiological responses of a single neuron using a microelectrode system. When a neuron generates an action potential, the signal propagates down the neuron as a current which flows in and out of the cell through excitable membrane regions in the soma and axon. A microelectrode is inserted into the brain, where it can record the rate of change in voltage with respect to time.

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