Publication

Immuno-affinity Amperometric Detection of Bacterial Infections

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Michel Prudent, Milica Jovic, Yingdi Zhu
2018
Journal Articles

Abstract

A combination of an immuno-affinity enrichment strategy and sensitive amperometric read-out was implemented in a point-of-care platform intended for bacterial infection analysis. Bacterial cells, selectively captured and enriched from complex matrices through immuno-affinity, were detected by amperometric monitoring of the redox state of metabolic activity indicators, providing species identification and viable-cell quantification. The method was successfully employed for the diagnosis of bacterial infections including antimicrobial susceptibility testing with only several hours of total working time.

Official source

https://infoscience.epfl.ch/entities/publication/f15fd08a-d830-4062-b3e4-2f9dab864e9e

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Hubert Girault, Horst Pick, Andreas Stephan Lesch, Michel Prudent, Milica Jovic, Yingdi Zhu
2018
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/f15fd08a-d830-4062-b3e4-2f9dab864e9e

About this result

Related concepts (13)

Bacterial adhesin

Adhesins are cell-surface components or appendages of bacteria that facilitate adhesion or adherence to other cells or to surfaces, usually in the host they are infecting or living in. Adhesins are a type of virulence factor. Adherence is an essential step in bacterial pathogenesis or infection, required for colonizing a new host. Adhesion and bacterial adhesins are also a potential target for prophylaxis or treatment of bacterial infections. Bacteria are typically found attached to and living in close association with surfaces.

Bacterial vaginosis

Bacterial vaginosis (BV) is an infection of the vagina caused by excessive growth of bacteria. Common symptoms include increased vaginal discharge that often smells like fish. The discharge is usually white or gray in color. Burning with urination may occur. Itching is uncommon. Occasionally, there may be no symptoms. Having BV approximately doubles the risk of infection by a number of sexually transmitted infections, including HIV/AIDS. It also increases the risk of early delivery among pregnant women.

Infection

An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection. Infections can be caused by a wide range of pathogens, most prominently bacteria and viruses. Hosts can fight infections using their immune systems. Mammalian hosts react to infections with an innate response, often involving inflammation, followed by an adaptive response.

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