Publication

Electrical modeling of the cell-electrode interface for recording neural activity from high-density microelectrode arrays

Alexandre Schmid, Yusuf Leblebici, Neil Joye
2009
Journal Articles

Abstract

Accurate electrical models are needed to support the design of modern microelectrode arrays. The point-contact model is presented thoroughly, and an area-contact model is analytically derived in order to model the electrical characteristics of the cell-electrode interface at subcellular resolution. An optimum electrode diameter for recording the electrical activity of neurons is analytically determined at 8 um, with a cell diameter of 10 um and a typical load capacitance of 10 pF. Finally, three- dimensional tip electrodes are characterized using the area- contact model. An improvement of the electrical coupling up to 20 dB is observed for small electrodes, in simulation.

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https://infoscience.epfl.ch/entities/publication/f43e4b28-e0af-457e-90dd-709e720c3a0b

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Alexandre Schmid, Yusuf Leblebici, Neil Joye
2009
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/f43e4b28-e0af-457e-90dd-709e720c3a0b

About this result

Related concepts (32)

Contact resistance

The term contact resistance refers to the contribution to the total resistance of a system which can be attributed to the contacting interfaces of electrical leads and connections as opposed to the intrinsic resistance. This effect is described by the term electrical contact resistance (ECR) and arises as the result of the limited areas of true contact at an interface and the presence of resistive surface films or oxide layers. ECR may vary with time, most often decreasing, in a process known as resistance creep.

Single-unit recording

In neuroscience, single-unit recordings (also, single-neuron recordings) provide a method of measuring the electro-physiological responses of a single neuron using a microelectrode system. When a neuron generates an action potential, the signal propagates down the neuron as a current which flows in and out of the cell through excitable membrane regions in the soma and axon. A microelectrode is inserted into the brain, where it can record the rate of change in voltage with respect to time.

Microelectrode array

Microelectrode arrays (MEAs) (also referred to as multielectrode arrays) are devices that contain multiple (tens to thousands) microelectrodes through which neural signals are obtained or delivered, essentially serving as neural interfaces that connect neurons to electronic circuitry. There are two general classes of MEAs: implantable MEAs, used in vivo, and non-implantable MEAs, used in vitro. Neurons and muscle cells create ion currents through their membranes when excited, causing a change in voltage between the inside and the outside of the cell.

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