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Programmable Multistable Mechanisms for Safe Surgical Puncturing

Related publications (30)

Unveiling the Rolling to Kayak Transition in Propelling Nanorods with Cargo Trapping and Pumping

Magnetic nanorods driven by rotating fields in water can be rapidly steered along any direction while generating strong and localized hydrodynamic flow fields. Here we show that, when raising the frequency of the rotating field, these nanopropellers underg ...

AMER CHEMICAL SOC2023

Acoustofluidic large-scale mixing for enhanced microfluidic immunostaining for tissue diagnostics

Martinus Gijs, Diego Gabriel Dupouy, Muaz Salama Abdelmonem Draz

The usage of microfluidics for automated and fast immunoassays has gained a lot of interest in the last decades. This integration comes with certain challenges, like the reconciliation of laminar flow patterns of micro-scale systems with diffusion-limited ...

ROYAL SOC CHEMISTRY2023

Efficient AC electrothermal flow (ACET) on-chip for enhanced immunoassays

Martinus Gijs, Diego Gabriel Dupouy, Muaz Salama Abdelmonem Draz

Biochemical reaction rates in microfluidic systems are known to be limited by the diffusional transport of reagents, leading often to lowered sensitivity and/or longer detection times in immunoassays. Several methods, including electrically powering electr ...

ROYAL SOC CHEMISTRY2023

lifex-ep: a robust and efficient software for cardiac electrophysiology simulations

Alfio Quarteroni, Francesco Regazzoni, Marco Fedele, Stefano Pagani

Background: Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-performance computational tools. Despite the dedicated endeavors ...

BMC2023

Influence of pore-scale heterogeneity on the precipitation patterns in Microbially Induced Calcite Precipitation (MICP)

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The principle of tailoring material properties to improve the mechanical behaviour of soils through compaction or cement grouting dates to the 60s. The increasing trends of urbanization worldwide require new solutions for the development of resilient and s ...

EPFL2023

Generalizing Bulk-Synchronous Parallel Processing for Data Science: From Data to Threads and Agent-Based Simulations

Zilu Tian

Agent-based simulations have been widely applied in many disciplines, by scientists and engineers alike. Scientists use agent-based simulations to tackle global problems, including alleviating poverty, reducing violence, and predicting the impact of pandem ...

EPFL2023

A neural probe to sample brain fluid in nanoliter volumes for quantitative molecular studies

Joan Teixidor

Neural functions operate in tightly controlled conditions that are mediated by multiple electrical and chemical phenomena. Brain disorders such as Parkinson's Disease and Alzheimer's Disease perturb these conditions and cause a loss of neurons, which impai ...

EPFL2022

Analytic modelling of passive microfluidic mixers

Christophe Lallement, Jean-Michel Sallese

This paper deals with a new analytical model for microfluidic passive mixers. Two common approaches already exist for such a purpose. On the one hand, the resolution of the advection-diffusion-reaction equation (ADRE) is the first one and the closest to ph ...

AMER INST MATHEMATICAL SCIENCES-AIMS2022

Dynamic Personalized Ranking

Jérémie Rappaz

Personalized ranking methods are at the core of many systems that learn to produce recommendations from user feedbacks. Their primary objective is to identify relevant items from very large vocabularies and to assist users in discovering new content. These ...

EPFL2022

Development of a freely distributable CFD tool for approximate and detailed simulations of the flow around a complex of buildings

Indo-Swiss Building Energy Efficiency Project (BEEP) is a cooperation project between the Ministry of Power, Government of India, and the Federal Department of Foreign Affairs of the Swiss Confederation. Started in 2011, the project's central focus is to h ...

IOP PUBLISHING LTD2021

Capacitive sensor to monitor the level of drug inside an injector pen

Sylvain Paul Fernand Joly

Diabete is a disease which is spreading faster than ever, impacting now a larger population. Patients suffering from this disease need the injection of insulin to control extracellular sugar levels. Pharmaceutical companies developed injector pens to allow ...

EPFL2021

Automated Analysis of Cerebrospinal Fluid Flow and Motile Cilia Properties in The Central Canal of Zebrafish Embryos

François Gallaire, Ludovic Pierre Gustave Keiser

Circulation of cerebrospinal fluid (CSF) plays an important role during development. In zebrafish embryo, the flow of CSF has been found to be bidirectional in the central canal of the spinal cord. In order to compare conditions and genetic mutants across ...

BIO-PROTOCOL2021

A new Euler-Lagrangian cavitation model for tip-vortex cavitation with the effect of non-condensable gas

Mohamed Farhat, Huaiyu Cheng

Numerical simulation of tip vortex cavitation (TVC) remains a challenging task in a variety of applica-tions, such as axial turbines and pumps as well as marine propellers. Although it is well known that TVC is highly sensitive to gas content, be it dissol ...

PERGAMON-ELSEVIER SCIENCE LTD2021

Bistable Puncturing Tool for Retinal Vein Cannulation

Simon Nessim Henein, Charles Baur, Yves Bellouard, Lisa Anaïs Jeanne Bonnefoy

An innovative surgical tool prototype dedicated to safe puncturing has been developed for the treatment of retinal vein occlusions (RVOs). The tool is manufactured monolithically by femtolaser printing in fused silica. It consists of a programmable bistabl ...

2020

Facile Fabrication of Microfluidic Chips for 3D Hydrodynamic Focusing and Wet Spinning of Polymeric Fibers

Fabien Sorin, Akin Gürsoy, Efe Armagan, Claudio Toncelli, René M. Rossi

Microfluidic wet spinning has gained increasing interest in recent years as an alternative to conventional wet spinning by offering higher control in fiber morphology and a gateway for the development of multi-material fibers. Conventionally, microfluidic ...

2020

Interaction and breakup of droplet pairs in a microchannel Y-junction

Tobias Schneider, Simon Sebastian Schütz

We combine theory, numerical simulation, and experiments to investigate the breakup of two identical droplets entering a Y-junction with controlled spatial offset by which the second droplet trails the first. Based on fully resolved 3D simulations, we desc ...

AMER PHYSICAL SOC2020

Three-dimensional electrodes for dielectrophoretic applications

Kevin Keim

This thesis reports the use of metal-coated three-dimensional SU-8 electrodes for dielectrophoretic bio sensing and particle manipulation applications. Placing free standing three-dimensional electrodes in microfluidic channels, electric fields can be appl ...

EPFL2020

From bulk descriptions to emergent interfaces: Connecting the Ginzburg-Landau and elastic-line models

Thierry Giamarchi, Elisabeth Agoritsas

Controlling interfaces is highly relevant from a technological point of view. However, their rich and complex behavior makes them very difficult to describe theoretically, and hence to predict. In this work, we establish a procedure to connect two levels o ...

2020

Minimum energy adaptive structures – All-In-One problem formulation

Gennaro Senatore, Yafeng Wang

This paper presents a new All-In-One (AIO) implementation of an existing formulation to design adaptive structures through Total Energy Optimization (TEO). The method implemented in previous work is a nested optimization process, here named TEO-Nested. Num ...

2020

Automated phenotyping of Caenorhabditis elegans embryos with a high-throughput-screening microfluidic platform

Martinus Gijs, Matteo Cornaglia, Hüseyin Baris Atakan, Tunç Alkanat, Raphaël Etienne Jean Trouillon

The nematode Caenorhabditis elegans has been extensively used as a model multicellular organism to study the influence of osmotic stress conditions and the toxicity of chemical compounds on developmental and motility-associated phenotypes. However, the sev ...

2020